Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Dongho Lee | - |
| dc.contributor.author | Jeong-Hyung Lee | - |
| dc.contributor.author | X F Cai | - |
| dc.contributor.author | Jin Chul Shin | - |
| dc.contributor.author | Kyeong Lee | - |
| dc.contributor.author | Young-Soo Hong | - |
| dc.contributor.author | Jung Joon Lee | - |
| dc.date.accessioned | 2017-04-19T09:03:38Z | - |
| dc.date.available | 2017-04-19T09:03:38Z | - |
| dc.date.issued | 2005 | - |
| dc.identifier.issn | 0021-8820 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7177 | - |
| dc.description.abstract | A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent. | - |
| dc.publisher | Springer-Nature Pub Group | - |
| dc.title | Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ | - |
| dc.title.alternative | Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Antibiotics | - |
| dc.citation.number | 10 | - |
| dc.citation.endPage | 620 | - |
| dc.citation.startPage | 615 | - |
| dc.citation.volume | 58 | - |
| dc.contributor.affiliatedAuthor | Dongho Lee | - |
| dc.contributor.affiliatedAuthor | Jeong-Hyung Lee | - |
| dc.contributor.affiliatedAuthor | Jin Chul Shin | - |
| dc.contributor.affiliatedAuthor | Kyeong Lee | - |
| dc.contributor.affiliatedAuthor | Young-Soo Hong | - |
| dc.contributor.affiliatedAuthor | Jung Joon Lee | - |
| dc.contributor.alternativeName | 이동호 | - |
| dc.contributor.alternativeName | 이정형 | - |
| dc.contributor.alternativeName | Cai | - |
| dc.contributor.alternativeName | 신진철 | - |
| dc.contributor.alternativeName | 이경 | - |
| dc.contributor.alternativeName | 홍영수 | - |
| dc.contributor.alternativeName | 이정준 | - |
| dc.identifier.bibliographicCitation | Journal of Antibiotics, vol. 58, no. 10, pp. 615-620 | - |
| dc.identifier.doi | 10.1038/ja.2005.84 | - |
| dc.subject.keyword | Nitric oxide | - |
| dc.subject.keyword | Peroxisome proliferator-activated receptor γ | - |
| dc.subject.keyword | Sorbicillinoid | - |
| dc.subject.keyword | Trichodimerol derivative | - |
| dc.subject.keyword | Tumor necrosis factor-α | - |
| dc.subject.local | NO | - |
| dc.subject.local | nitric oxide | - |
| dc.subject.local | nitric oxide (NO) | - |
| dc.subject.local | Nitric oxide | - |
| dc.subject.local | NO (Nitric oxide) | - |
| dc.subject.local | nitric oxide. | - |
| dc.subject.local | Nitric oxid | - |
| dc.subject.local | Nitric oxide (NO) | - |
| dc.subject.local | Peroxisome proliferator-activated receptor γ | - |
| dc.subject.local | peroxisome proliferators-activated receptor γ | - |
| dc.subject.local | Sorbicillinoid | - |
| dc.subject.local | Trichodimerol derivative | - |
| dc.subject.local | Tumor necrosis fa tor-α | - |
| dc.subject.local | TNFα | - |
| dc.subject.local | Tumor necrosis factor (TNF)-α | - |
| dc.subject.local | Tnf-α | - |
| dc.subject.local | TNF-a | - |
| dc.subject.local | TNF-alpha | - |
| dc.subject.local | Tumor necrosis factor-α | - |
| dc.subject.local | tumor necrosis factor-alpha | - |
| dc.subject.local | TNFa | - |
| dc.subject.local | Tumor necrosis factor alpha | - |
| dc.subject.local | Tumor necrosis factor-alpha | - |
| dc.subject.local | TNF-α | - |
| dc.subject.local | tumor necrosis factor-α | - |
| dc.description.journalClass | Y | - |
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