Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

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dc.contributor.authorDongho Lee-
dc.contributor.authorJeong-Hyung Lee-
dc.contributor.authorX F Cai-
dc.contributor.authorJin Chul Shin-
dc.contributor.authorKyeong Lee-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorJung Joon Lee-
dc.date.accessioned2017-04-19T09:03:38Z-
dc.date.available2017-04-19T09:03:38Z-
dc.date.issued2005-
dc.identifier.issn0021-8820-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7177-
dc.description.abstractA new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.-
dc.publisherSpringer-Nature Pub Group-
dc.titleFungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ-
dc.title.alternativeFungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ-
dc.typeArticle-
dc.citation.titleJournal of Antibiotics-
dc.citation.number10-
dc.citation.endPage620-
dc.citation.startPage615-
dc.citation.volume58-
dc.contributor.affiliatedAuthorDongho Lee-
dc.contributor.affiliatedAuthorJeong-Hyung Lee-
dc.contributor.affiliatedAuthorJin Chul Shin-
dc.contributor.affiliatedAuthorKyeong Lee-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeName이동호-
dc.contributor.alternativeName이정형-
dc.contributor.alternativeNameCai-
dc.contributor.alternativeName신진철-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName이정준-
dc.identifier.bibliographicCitationJournal of Antibiotics, vol. 58, no. 10, pp. 615-620-
dc.identifier.doi10.1038/ja.2005.84-
dc.subject.keywordNitric oxide-
dc.subject.keywordPeroxisome proliferator-activated receptor γ-
dc.subject.keywordSorbicillinoid-
dc.subject.keywordTrichodimerol derivative-
dc.subject.keywordTumor necrosis factor-α-
dc.subject.localNO-
dc.subject.localnitric oxide-
dc.subject.localnitric oxide (NO)-
dc.subject.localNitric oxide-
dc.subject.localNO (Nitric oxide)-
dc.subject.localnitric oxide.-
dc.subject.localNitric oxid-
dc.subject.localNitric oxide (NO)-
dc.subject.localPeroxisome proliferator-activated receptor γ-
dc.subject.localperoxisome proliferators-activated receptor γ-
dc.subject.localSorbicillinoid-
dc.subject.localTrichodimerol derivative-
dc.subject.localTumor necrosis fa tor-α-
dc.subject.localTNFα-
dc.subject.localTumor necrosis factor (TNF)-α-
dc.subject.localTnf-α-
dc.subject.localTNF-a-
dc.subject.localTNF-alpha-
dc.subject.localTumor necrosis factor-α-
dc.subject.localtumor necrosis factor-alpha-
dc.subject.localTNFa-
dc.subject.localTumor necrosis factor alpha-
dc.subject.localTumor necrosis factor-alpha-
dc.subject.localTNF-α-
dc.subject.localtumor necrosis factor-α-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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