Suppression of matrix Metalloproteinase-9 expression of flavonoids from Metasequoia glyptostroboides = 낙우송(Metasequoia glyptostroboides)으로부터 분리한 flavonoid의 금속단백분해효소-9 발현 억제 활성

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Title
Suppression of matrix Metalloproteinase-9 expression of flavonoids from Metasequoia glyptostroboides = 낙우송(Metasequoia glyptostroboides)으로부터 분리한 flavonoid의 금속단백분해효소-9 발현 억제 활성
Author(s)
Jae-Young Yang; Ho Jae Lee; Yung Hee Kho; Byoung-Mog Kwon; Hyo Kon Chun
Bibliographic Citation
Korean Journal of Life Sciences, vol. 15, no. 2, pp. 231-235
Publication Year
2005
Abstract
Matrix metalloproteinases (MMPs) are a family of structurally and functionally related zinc-dependent enzymes responsible for proteolytic degradation of extracellular matrix components such as base membrane or interstitial stroma. MMPs play an important role in a variety of physiological and pathological tissue remodeling processes, including wound healing, embryo implantation, tumor invasion and metastasis. Since MMP-9 (gelatinase B) has unique ability to cleave type Ⅳ collagen, gene expression of MMP-9 has been focused on as a pharmacological target. Flavonoids are a class of compounds that are widely spread in plants. In the coures of screening for the suppressors of MMP-9 gene expression from natural products, Metasequoia glyptostroboides was selected. Six flavonoids, sciadopitysin, isoginkgetin, bilobetin, 2,3-dihydrohinokiflavone, luteolin and apigenin were purified as suppressors of MMP-9 gene expression from M. glyptostroboides. The suppressing activity of the isolated flavinoids on the MMP-9 gene expression was measured by gelatin zymography and Nothern blot analysis.
Keyword
MMPsECMMetasequoia glyptostrobodiesflavonoid
ISSN
I000-0052
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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