Apolipoprotein A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation

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dc.contributor.authorKwang Dong Kim-
dc.contributor.authorHo Yong Lim-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorDo Young Yoon-
dc.contributor.authorYong Kyung Choe-
dc.contributor.authorIn Pyo Choi-
dc.contributor.authorS G Paik-
dc.contributor.authorY S Kim-
dc.contributor.authorY Yang-
dc.contributor.authorJ S Lim-
dc.date.accessioned2017-04-19T09:03:39Z-
dc.date.available2017-04-19T09:03:39Z-
dc.date.issued2005-
dc.identifier.issn0006291X-
dc.identifier.uri10.1016/j.bbrc.2005.10.065ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7185-
dc.description.abstractApolipoprotein A-I (apoA-I), the major protein component of serum high-density lipoprotein, exhibits anti-inflammatory activity in atherosclerosis. In this study, we demonstrate that apoA-I inhibits DC differentiation and maturation. DC differentiated from monocytes in the presence of apoA-I showed a decreased expression of surface molecules such as CD1a, CD80, CD86, and HLA-DR. In addition, these DC exhibited decreased endocytic activity and weakened allogeneic T-cell activation. During DC differentiation in the presence of apoA-I, PGE2 and IL-10, which are known to be DC differentiation inhibitors and/or modulators of DC function, were produced at remarkable rates, whereas IL-12 production in the cells after stimulation with CD40 mAb and IFN-γ was significantly decreased in comparison with the control DC. T cells stimulated by apoA-I-pretreated DC produced significantly low levels of IFN-γ, and apoA-I inhibited cross-talk between DC and NK cells, in terms of IL-12 and IFN-γ production. Therefore, apoA-I appears to play an important role in modulating both innate immune response and inflammatory response. The novel inhibitory function of apoA-I on DC differentiation and function may facilitate the development of new therapeutic interventions in inflammatory diseases.-
dc.publisherElsevier-
dc.titleApolipoprotein A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation-
dc.title.alternativeApolipoprotein A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage1136-
dc.citation.startPage1126-
dc.citation.volume338-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName김광동-
dc.contributor.alternativeName임호용-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName최용경-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName백상기-
dc.contributor.alternativeName김영상-
dc.contributor.alternativeName양영-
dc.contributor.alternativeName임종석-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 338, no. 2, pp. 1126-1136-
dc.identifier.doi10.1016/j.bbrc.2005.10.065-
dc.subject.keywordApolipoprotein A-I-
dc.subject.keywordDendritic cells-
dc.subject.keywordIL-10-
dc.subject.keywordNatural killer cells-
dc.subject.keywordPGE2-
dc.subject.localApolipoprotein A-I-
dc.subject.localDendritic cells-
dc.subject.localDendritic cell-
dc.subject.localIL-10-
dc.subject.localNatural killer cells-
dc.subject.localNatural killer cell-
dc.subject.localPGE2-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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