Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation = Cyclic diarylheptanoids의 항산화 효과

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Title
Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation = Cyclic diarylheptanoids의 항산화 효과
Author(s)
Hyun Mi Kang; Ju Ryong Kim; Tae Sook Jeong; Sung Gyu Choi; Y H Ryu; G T Oh; N I Baek; Byoung-Mog Kwon
Bibliographic Citation
Natural Product Research, vol. 20, no. 2, pp. 139-143
Publication Year
2006
Abstract
Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC 50 values of 2.9 and 1.7 μM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.
Keyword
Alnus japonicaDiarylheptanoidsLow-density lipoprotein oxidation
ISSN
1029-2349
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/14786410500045895
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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