New cytotoxic benzopyrans from the leaves of Mallotus apelta

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Title
New cytotoxic benzopyrans from the leaves of Mallotus apelta
Author(s)
P V Kiem; N H Dang; H V Bao; H T Huong; C V Minh; L M Huong; Jung Joon Lee; Y H Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 10, pp. 1131-1134
Publication Year
2005
Abstract
Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5,7- dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)- methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC 50: 0.49 μg/mL) and rhabdosarcoma (RD, IC50: 0.54 μg/mL), while compound 2 showed moderate activity against Hep-2 cell line (IC50, 4.22 μg/mL) by in vitro assay.
Keyword
benzopyrancytotoxic activityeuphorbiaceaemallotus apelta
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/bf02972974
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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