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- Title
- A potent anti-complementary acylated sterol glucoside from Orostachys japonicus
- Author(s)
- N Y Yoon; B S Min; Hyeong Kyu Lee; J C Park; J S Choi
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 28, no. 8, pp. 892-896
- Publication Year
- 2005
- Abstract
- In order to isolate substances that inhibit the hemolytic activity of human serum against erythrocytes, we have evaluated whole plants of the Orostachys japonicus species with regard to its anti-complement activity, and have identified its active principles following activity-guided isolation. A methanol extract of the O. japonicus, as well as its n-hexane soluble fraction, exhibited significant anti-complement activity on the complement system, which was expressed as total hemolytic activity. A bioassay-guided chromatographic separation of the constituents resulted in the isolation of three known compounds 1-3 from the active n-hexane fraction. The structure of these compounds were analyzed, and they were identified as hydroxyhopanone (1), β-sitosteryl-3-O-β-D-glucopyranosyl-6′-O-palmitate (2), and β-sitosteryl-3-O-β-D-glucopyranoside (3), respectively. of these compounds, compound 2 exhibited potent anti-complement activity (IC50 = 1.0 ± 0.1 μM) on the classical pathway of the complement, as compared to tiliroside (IC50 = 76.5 ± 1.1 μM), which was used as a positive control. However, compounds 1 and 3 exhibited no activity in this system.
- Keyword
- β-sitosteryl-3-o-β-d-glucopyranosyl-6′-o-palmitateanti-complement activitycrassulaceaeorostachys japonicus a. berger
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- DOI
- http://dx.doi.org/10.1007/bf02973873
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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