A potent anti-complementary acylated sterol glucoside from Orostachys japonicus

Cited 29 time in scopus
Metadata Downloads
Title
A potent anti-complementary acylated sterol glucoside from Orostachys japonicus
Author(s)
N Y Yoon; B S Min; Hyeong Kyu Lee; J C Park; J S Choi
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 8, pp. 892-896
Publication Year
2005
Abstract
In order to isolate substances that inhibit the hemolytic activity of human serum against erythrocytes, we have evaluated whole plants of the Orostachys japonicus species with regard to its anti-complement activity, and have identified its active principles following activity-guided isolation. A methanol extract of the O. japonicus, as well as its n-hexane soluble fraction, exhibited significant anti-complement activity on the complement system, which was expressed as total hemolytic activity. A bioassay-guided chromatographic separation of the constituents resulted in the isolation of three known compounds 1-3 from the active n-hexane fraction. The structure of these compounds were analyzed, and they were identified as hydroxyhopanone (1), β-sitosteryl-3-O-β-D-glucopyranosyl-6′-O-palmitate (2), and β-sitosteryl-3-O-β-D-glucopyranoside (3), respectively. of these compounds, compound 2 exhibited potent anti-complement activity (IC50 = 1.0 ± 0.1 μM) on the classical pathway of the complement, as compared to tiliroside (IC50 = 76.5 ± 1.1 μM), which was used as a positive control. However, compounds 1 and 3 exhibited no activity in this system.
Keyword
β-sitosteryl-3-o-β-d-glucopyranosyl-6′-o-palmitateanti-complement activitycrassulaceaeorostachys japonicus a. berger
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/bf02973873
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.