Stronger anti-HIV-1 activity of C-peptide derived from HIV-I89.6 gp41 C-terminal heptad repeated sequence = 인간면역바이러스 89.6형에서 유래한 C-peptide의 강한 항 인간면역바이러스 활성

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dc.contributor.authorJeong Kon Seo-
dc.contributor.authorHee Kyung Kim-
dc.contributor.authorTae Young Lee-
dc.contributor.authorK S Hahm-
dc.contributor.authorK L Kim-
dc.contributor.authorMyung Kyu Lee-
dc.date.accessioned2017-04-19T09:03:45Z-
dc.date.available2017-04-19T09:03:45Z-
dc.date.issued2005-
dc.identifier.issn01969781-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7213-
dc.description.abstractC34-LAI containing amino acids 118 to 151 of the HIV-1LAI gp41 ectodomain exhibits potent anti-HIV-1 activity. However, the N-terminal halves of C34 peptides vary more according to the HIV-1 strain than the C-terminal halves. Therefore, an analysis was conducted on the anti-HIV-1 activities of the C34 peptides derived from various HIV-1 strains. C34-89.6 exhibited the strongest anti-HIV-1 activity among the C34 peptides tested. Interestingly, its N-terminal half was more acidic than those of the other C34 peptides, whereas its C-terminal half was more basic. Since the C-peptides derived from the HIV-1LAI strain are used extensively, the anti-HIV-1 activities of these peptides were compared between the HIV-1 strains 89.6 and LAI. When using chimeric peptides, it was found that the C-terminal basic region of C34-89.6 was more critical than its N-terminal basic region. The anti-HIV-1 activity of T20-89.6 and C28-89.6 was also stronger than that of T20-LAI and C28-LAI, respectively. The anti-HIV-1 activity of C28-89.6 was weakened when the C-terminal basic residues were changed to the corresponding residues of C28-LAI. However, no conformational differences were found among the C28 peptides. Accordingly, these results imply that introducing the C-terminal basic residues of the HIV-189.6 C-peptide may be useful for developing potent anti-HIV-1 drugs.-
dc.publisherElsevier-
dc.titleStronger anti-HIV-1 activity of C-peptide derived from HIV-I89.6 gp41 C-terminal heptad repeated sequence = 인간면역바이러스 89.6형에서 유래한 C-peptide의 강한 항 인간면역바이러스 활성-
dc.title.alternativeStronger anti-HIV-1 activity of C-peptide derived from HIV-I89.6 gp41 C-terminal heptad repeated sequence-
dc.typeArticle-
dc.citation.titlePeptides-
dc.citation.number11-
dc.citation.endPage2181-
dc.citation.startPage2175-
dc.citation.volume26-
dc.contributor.affiliatedAuthorMyung Kyu Lee-
dc.contributor.alternativeName서정곤-
dc.contributor.alternativeName김희경-
dc.contributor.alternativeName이태영-
dc.contributor.alternativeName함경수-
dc.contributor.alternativeName김길룡-
dc.contributor.alternativeName이명규-
dc.identifier.bibliographicCitationPeptides, vol. 26, no. 11, pp. 2175-2181-
dc.identifier.doi10.1016/j.peptides.2005.04.006-
dc.subject.keywordanti-HIV-1 assay-
dc.subject.keywordanti-HIV-1 peptide-
dc.subject.keywordC-peptide of HIV-1 gp41-
dc.subject.keywordHIV-189.6 strain-
dc.subject.localanti-HIV-1 assay-
dc.subject.localanti-HIV-1 peptide-
dc.subject.localC-peptide of HIV-1 gp41-
dc.subject.localHIV-189.6 strain-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
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