DC Field | Value | Language |
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dc.contributor.author | Jeong Kon Seo | - |
dc.contributor.author | Hee Kyung Kim | - |
dc.contributor.author | Tae Young Lee | - |
dc.contributor.author | K S Hahm | - |
dc.contributor.author | K L Kim | - |
dc.contributor.author | Myung Kyu Lee | - |
dc.date.accessioned | 2017-04-19T09:03:45Z | - |
dc.date.available | 2017-04-19T09:03:45Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7213 | - |
dc.description.abstract | C34-LAI containing amino acids 118 to 151 of the HIV-1LAI gp41 ectodomain exhibits potent anti-HIV-1 activity. However, the N-terminal halves of C34 peptides vary more according to the HIV-1 strain than the C-terminal halves. Therefore, an analysis was conducted on the anti-HIV-1 activities of the C34 peptides derived from various HIV-1 strains. C34-89.6 exhibited the strongest anti-HIV-1 activity among the C34 peptides tested. Interestingly, its N-terminal half was more acidic than those of the other C34 peptides, whereas its C-terminal half was more basic. Since the C-peptides derived from the HIV-1LAI strain are used extensively, the anti-HIV-1 activities of these peptides were compared between the HIV-1 strains 89.6 and LAI. When using chimeric peptides, it was found that the C-terminal basic region of C34-89.6 was more critical than its N-terminal basic region. The anti-HIV-1 activity of T20-89.6 and C28-89.6 was also stronger than that of T20-LAI and C28-LAI, respectively. The anti-HIV-1 activity of C28-89.6 was weakened when the C-terminal basic residues were changed to the corresponding residues of C28-LAI. However, no conformational differences were found among the C28 peptides. Accordingly, these results imply that introducing the C-terminal basic residues of the HIV-189.6 C-peptide may be useful for developing potent anti-HIV-1 drugs. | - |
dc.publisher | Elsevier | - |
dc.title | Stronger anti-HIV-1 activity of C-peptide derived from HIV-I89.6 gp41 C-terminal heptad repeated sequence = 인간면역바이러스 89.6형에서 유래한 C-peptide의 강한 항 인간면역바이러스 활성 | - |
dc.title.alternative | Stronger anti-HIV-1 activity of C-peptide derived from HIV-I89.6 gp41 C-terminal heptad repeated sequence | - |
dc.type | Article | - |
dc.citation.title | Peptides | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 2181 | - |
dc.citation.startPage | 2175 | - |
dc.citation.volume | 26 | - |
dc.contributor.affiliatedAuthor | Jeong Kon Seo | - |
dc.contributor.affiliatedAuthor | Hee Kyung Kim | - |
dc.contributor.affiliatedAuthor | Tae Young Lee | - |
dc.contributor.affiliatedAuthor | Myung Kyu Lee | - |
dc.contributor.alternativeName | 서정곤 | - |
dc.contributor.alternativeName | 김희경 | - |
dc.contributor.alternativeName | 이태영 | - |
dc.contributor.alternativeName | 함경수 | - |
dc.contributor.alternativeName | 김길룡 | - |
dc.contributor.alternativeName | 이명규 | - |
dc.identifier.bibliographicCitation | Peptides, vol. 26, no. 11, pp. 2175-2181 | - |
dc.identifier.doi | 10.1016/j.peptides.2005.04.006 | - |
dc.subject.keyword | anti-HIV-1 assay | - |
dc.subject.keyword | anti-HIV-1 peptide | - |
dc.subject.keyword | C-peptide of HIV-1 gp41 | - |
dc.subject.keyword | HIV-189.6 strain | - |
dc.subject.local | anti-HIV-1 assay | - |
dc.subject.local | anti-HIV-1 peptide | - |
dc.subject.local | C-peptide of HIV-1 gp41 | - |
dc.subject.local | HIV-189.6 strain | - |
dc.description.journalClass | Y | - |
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