DC Field | Value | Language |
---|---|---|
dc.contributor.author | K S Kim | - |
dc.contributor.author | D Y Cho | - |
dc.contributor.author | Young Joo Kim | - |
dc.contributor.author | S M Choi | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | S U Shin | - |
dc.contributor.author | Y S Yoon | - |
dc.date.accessioned | 2017-04-19T09:03:54Z | - |
dc.date.available | 2017-04-19T09:03:54Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.uri | 10.1016/j.bbadis.2004.11.026 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7230 | - |
dc.description.abstract | A-1766G polymorphism, for the first time, has been found in the sequencing of pooled and individual genomic DNA of Korean subjects at the 5′ flanking region of the UCP-1 gene. The effects of new polymorphism on body fat were elucidated among 387 Korean female subjects. It was shown that the genotypes AA, AG, and GG were consisted of 57.4%, 37.7%, and 4.9%, respectively, which was in agreement with Hardy-Weinberg equilibrium (P=0.327). The frequency of major A allele was 0.762 and that of minor G allele was 0.238. It is found that the waist-hip ratio (WHR) (P=0.008), body fat mass (P=0.023), and percent body fat (P=0.014) are significantly higher in the AG/GG type compared to the AA type. When the subjects were analyzed using computerized tomography, there were significant increases in the AG/GG type compared to the AA type in the abdominal subcutaneous fat (P=0.015) and the abdominal visceral fat (P=0.013), respectively. A-1766G is approximately 2 kb downstream from the well-known A-3826G polymorphism, and no linkage between them was found (D′=0.929, R2=0.283). Three haplotypes (frequency >0.05) were examined from two polymorphisms and studied for their physiological effects. It was found that haplotype [GG] was significantly associated with increased body fat, while haplotype [GA] was associated with decreased body fat. | - |
dc.publisher | Elsevier | - |
dc.title | The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation | - |
dc.title.alternative | The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation | - |
dc.type | Article | - |
dc.citation.title | Biochimica et Biophysica Acta-Molecular Basis of Disease | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 155 | - |
dc.citation.startPage | 149 | - |
dc.citation.volume | 1741 | - |
dc.contributor.affiliatedAuthor | Young Joo Kim | - |
dc.contributor.alternativeName | 김길수 | - |
dc.contributor.alternativeName | 조대연 | - |
dc.contributor.alternativeName | 김영주 | - |
dc.contributor.alternativeName | 최선미 | - |
dc.contributor.alternativeName | 김종열 | - |
dc.contributor.alternativeName | 신승우 | - |
dc.contributor.alternativeName | 윤유식 | - |
dc.identifier.bibliographicCitation | Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1741, no. 1, pp. 149-155 | - |
dc.identifier.doi | 10.1016/j.bbadis.2004.11.026 | - |
dc.subject.keyword | A-1766G | - |
dc.subject.keyword | fat | - |
dc.subject.keyword | haplotype | - |
dc.subject.keyword | polymorphism | - |
dc.subject.keyword | SNP | - |
dc.subject.keyword | UCP-1 | - |
dc.subject.local | A-1766G | - |
dc.subject.local | Fat | - |
dc.subject.local | fat | - |
dc.subject.local | haplotype | - |
dc.subject.local | Haplotype | - |
dc.subject.local | polymorphism | - |
dc.subject.local | Polymorphism | - |
dc.subject.local | SNP | - |
dc.subject.local | SNPs | - |
dc.subject.local | UCP1 | - |
dc.subject.local | UCP-1 | - |
dc.description.journalClass | Y | - |
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