The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation

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dc.contributor.authorK S Kim-
dc.contributor.authorD Y Cho-
dc.contributor.authorYoung Joo Kim-
dc.contributor.authorS M Choi-
dc.contributor.authorJ Y Kim-
dc.contributor.authorS U Shin-
dc.contributor.authorY S Yoon-
dc.date.accessioned2017-04-19T09:03:54Z-
dc.date.available2017-04-19T09:03:54Z-
dc.date.issued2005-
dc.identifier.issn0925-4439-
dc.identifier.uri10.1016/j.bbadis.2004.11.026ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7230-
dc.description.abstractA-1766G polymorphism, for the first time, has been found in the sequencing of pooled and individual genomic DNA of Korean subjects at the 5′ flanking region of the UCP-1 gene. The effects of new polymorphism on body fat were elucidated among 387 Korean female subjects. It was shown that the genotypes AA, AG, and GG were consisted of 57.4%, 37.7%, and 4.9%, respectively, which was in agreement with Hardy-Weinberg equilibrium (P=0.327). The frequency of major A allele was 0.762 and that of minor G allele was 0.238. It is found that the waist-hip ratio (WHR) (P=0.008), body fat mass (P=0.023), and percent body fat (P=0.014) are significantly higher in the AG/GG type compared to the AA type. When the subjects were analyzed using computerized tomography, there were significant increases in the AG/GG type compared to the AA type in the abdominal subcutaneous fat (P=0.015) and the abdominal visceral fat (P=0.013), respectively. A-1766G is approximately 2 kb downstream from the well-known A-3826G polymorphism, and no linkage between them was found (D′=0.929, R2=0.283). Three haplotypes (frequency >0.05) were examined from two polymorphisms and studied for their physiological effects. It was found that haplotype [GG] was significantly associated with increased body fat, while haplotype [GA] was associated with decreased body fat.-
dc.publisherElsevier-
dc.titleThe finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation-
dc.title.alternativeThe finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation-
dc.typeArticle-
dc.citation.titleBiochimica et Biophysica Acta-Molecular Basis of Disease-
dc.citation.number1-
dc.citation.endPage155-
dc.citation.startPage149-
dc.citation.volume1741-
dc.contributor.affiliatedAuthorYoung Joo Kim-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName조대연-
dc.contributor.alternativeName김영주-
dc.contributor.alternativeName최선미-
dc.contributor.alternativeName김종열-
dc.contributor.alternativeName신승우-
dc.contributor.alternativeName윤유식-
dc.identifier.bibliographicCitationBiochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1741, no. 1, pp. 149-155-
dc.identifier.doi10.1016/j.bbadis.2004.11.026-
dc.subject.keywordA-1766G-
dc.subject.keywordfat-
dc.subject.keywordhaplotype-
dc.subject.keywordpolymorphism-
dc.subject.keywordSNP-
dc.subject.keywordUCP-1-
dc.subject.localA-1766G-
dc.subject.localFat-
dc.subject.localfat-
dc.subject.localhaplotype-
dc.subject.localHaplotype-
dc.subject.localpolymorphism-
dc.subject.localPolymorphism-
dc.subject.localSNP-
dc.subject.localSNPs-
dc.subject.localUCP1-
dc.subject.localUCP-1-
dc.description.journalClassY-
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