Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model

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Title
Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model
Author(s)
Jung Won Youm; H Kim; J H L Han; C H Jang; H J Ha; I Mook-Jung; Jae Heung Jeon; C Y Choi; Y H Kim; Hyun Soon Kim; Hyouk Joung
Bibliographic Citation
FEBS Letters, vol. 579, no. 30, pp. 6737-6744
Publication Year
2005
Abstract
Beta amyloid (Aβ) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of Aβ is considered a primary therapeutic target. Immunization with Aβ can reduce Aβ burden and pathological features in transgenic AD model mice. Transgenic potato plants were made using genes encoding 5 tandem repeats of Aβ1-42 peptides with an ER retention signal. Amyloid precursor protein transgenic mice (Tg2576) fed with transgenic potato tubers with adjuvant showed a primary immune response and a partial reduction of Aβ burden in the brain. Thus, Aβ tandem repeats can be expressed in transgenic potato plants to form immunologically functional Aβ, and these potatoes has a potential to be used for the prevention and treatment of AD.
Keyword
alzheimer's diseasebeta amyloidoral immunizationpotatotransgenic plant
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2005.11.003
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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