T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene = 퍼록시레독신 II 결손에 의한 T 임파구와 DC의 활성화 연구

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Title
T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene = 퍼록시레독신 II 결손에 의한 T 임파구와 DC의 활성화 연구
Author(s)
Eun Yi Moon; Y W Noh; Ying Hao Han; Sun-Uk Kim; J M Kim; Dae Yeul Yu; J S Lim
Bibliographic Citation
Immunology Letters, vol. 102, no. 2, pp. 184-190
Publication Year
2006
Abstract
Peroxiredoxin II (Prx II) is a member of antioxidant enzyme family and it plays a protective role against oxidative damage. Constitutive production of endogenous reactive oxygen species was detected in spleen and bone marrow cells lacking Prx II. Here, we investigated the role of Prx II in immune responses. The total number of splenocytes (especially, the population of S-phase cells and CD3+ T cells) was significantly higher in Prx II-/- mice than in wild type. Number of peripheral blood mononuclear cells (PBMCs) in Prx II-/- mice was also higher than wild type. Differentiation of Prx II-/- mouse bone marrow cells into CD11c-positive dendritic cells was greater than that of wild type. Transplantation of Prx II-/- bone marrow cells into wild type mice increased PBMCs in blood and bone marrow-derived dendritic cells. Prx II deletion enhances concanavalin A (ConA)-induced splenocyte proliferation and mixed lymphocyte reaction (MLR) activity of bone marrow-derived CD11c-positive dendritic cells to stimulate recipient splenocytes. Collectively, these data suggest that Prx II inhibits the immune cell responsiveness, which may be regulated by scavenging the low amount of reactive oxygen species (ROS).
Keyword
dendritic cellperoxiredoxin II (Prx II)reactive oxygen species (ROS)T lymphocyte
ISSN
0165-2478
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.imlet.2005.09.003
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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