Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

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dc.contributor.authorX H Han-
dc.contributor.authorS S Hong-
dc.contributor.authorJ S Hwang-
dc.contributor.authorS H Jeong-
dc.contributor.authorJ H Hwang-
dc.contributor.authorM H Lee-
dc.contributor.authorM K Lee-
dc.contributor.authorDongho Lee-
dc.contributor.authorJ S Ro-
dc.contributor.authorB Y Hwang-
dc.date.accessioned2017-04-19T09:04:01Z-
dc.date.available2017-04-19T09:04:01Z-
dc.date.issued2005-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7268-
dc.description.abstractA methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.-
dc.publisherPharmaceutical Soc Korea-
dc.titleMonoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata-
dc.title.alternativeMonoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number12-
dc.citation.endPage1327-
dc.citation.startPage1324-
dc.citation.volume28-
dc.contributor.affiliatedAuthorDongho Lee-
dc.contributor.alternativeNameHan-
dc.contributor.alternativeName홍성수-
dc.contributor.alternativeName황지상-
dc.contributor.alternativeName정선화-
dc.contributor.alternativeName황지혜-
dc.contributor.alternativeName이민희-
dc.contributor.alternativeName이명구-
dc.contributor.alternativeName이동호-
dc.contributor.alternativeName노재섭-
dc.contributor.alternativeName황방연-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 28, no. 12, pp. 1324-1327-
dc.subject.keywordcudrania tricuspidata-
dc.subject.keywordgancaonin A-
dc.subject.keywordmonoamine oxidase inhibitor-
dc.subject.keywordmoraceae-
dc.subject.keywordprenylated isoflavone-
dc.subject.localcudrania tricuspidata-
dc.subject.localCudrania tricuspidata-
dc.subject.localgancaonin A-
dc.subject.localmonoamine oxidase inhibitor-
dc.subject.localmoraceae-
dc.subject.localMoraceae-
dc.subject.localprenylated isoflavone-
dc.description.journalClassY-
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