Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis

Cited 29 time in scopus
Metadata Downloads
Title
Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis
Author(s)
P V Kiem; C V Minh; H T Huong; Jung Joon Lee; I S Lee; Y H Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 12, pp. 1345-1349
Publication Year
2005
Abstract
Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2′,3′-dihydroxy-4′,6′-dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. of these constituents, compounds 2 (IC50: 3.89 ± 0.39 μM) and 3 (IC50: 9.77 ± 0.26 μM) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 (IC50: 28.4 ± 2.62 μM) exhibited moderate inhibitory activity.
Keyword
Desmos chinensisNFAT transcription factorPhenolic constituents
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977900
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.