Open Access@KRIBBDivision of Research on National ChallengesBionanotechnology Research Center1. Journal Articles
Protein tyrosine phosphatase 1B inhibitors from Morus root bark
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | L Cui | - |
| dc.contributor.author | Min Kyun Na | - |
| dc.contributor.author | H Oh | - |
| dc.contributor.author | Eun Young Bae | - |
| dc.contributor.author | Dae Gwin Jeong | - |
| dc.contributor.author | Seong Eon Ryu | - |
| dc.contributor.author | S Kim | - |
| dc.contributor.author | Bo Yeon Kim | - |
| dc.contributor.author | Won Keun Oh | - |
| dc.contributor.author | Jong Seog Ahn | - |
| dc.date.accessioned | 2017-04-19T09:04:03Z | - |
| dc.date.available | 2017-04-19T09:04:03Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | 10.1016/j.bmcl.2005.11.071 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7281 | - |
| dc.description.abstract | An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1-4 inhibited PTP1B with IC50 values ranging from 1.6 ± 0.3 μM to 16.9 ± 1.1 μM. | - |
| dc.publisher | Elsevier | - |
| dc.title | Protein tyrosine phosphatase 1B inhibitors from Morus root bark | - |
| dc.title.alternative | Protein tyrosine phosphatase 1B inhibitors from Morus root bark | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
| dc.citation.number | 5 | - |
| dc.citation.endPage | 1429 | - |
| dc.citation.startPage | 1426 | - |
| dc.citation.volume | 16 | - |
| dc.contributor.affiliatedAuthor | Min Kyun Na | - |
| dc.contributor.affiliatedAuthor | Eun Young Bae | - |
| dc.contributor.affiliatedAuthor | Dae Gwin Jeong | - |
| dc.contributor.affiliatedAuthor | Seong Eon Ryu | - |
| dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
| dc.contributor.affiliatedAuthor | Won Keun Oh | - |
| dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
| dc.contributor.alternativeName | Cui | - |
| dc.contributor.alternativeName | 나민균 | - |
| dc.contributor.alternativeName | 오현철 | - |
| dc.contributor.alternativeName | 배은영 | - |
| dc.contributor.alternativeName | 정대균 | - |
| dc.contributor.alternativeName | 류성언 | - |
| dc.contributor.alternativeName | 김소희 | - |
| dc.contributor.alternativeName | 김보연 | - |
| dc.contributor.alternativeName | 오원근 | - |
| dc.contributor.alternativeName | 안종석 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 5, pp. 1426-1429 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2005.11.071 | - |
| dc.subject.keyword | kuwanon L. | - |
| dc.subject.keyword | morus root bark | - |
| dc.subject.keyword | mulberrofuran C | - |
| dc.subject.keyword | protein tyrosine phosphatase 1B | - |
| dc.subject.keyword | sanggenon C | - |
| dc.subject.keyword | sanggenon G | - |
| dc.subject.local | kuwanon L. | - |
| dc.subject.local | morus root bark | - |
| dc.subject.local | mulberrofuran C | - |
| dc.subject.local | protein tyrosine phosphatase 1B | - |
| dc.subject.local | protein tyrosine phosphatase-1B (PTP1B) | - |
| dc.subject.local | Protein tyrosine phosphatase 1B | - |
| dc.subject.local | protein tyrosine phosphatase 1B (PTP1B) | - |
| dc.subject.local | protein tyrosine phosphatase 1B (FTPIB) | - |
| dc.subject.local | Protein tyrosine phosphatase 1B (PTP1B) | - |
| dc.subject.local | sanggenon C | - |
| dc.subject.local | sanggenon G | - |
| dc.description.journalClass | Y | - |
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- Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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