DC Field | Value | Language |
---|---|---|
dc.contributor.author | Woo Song Lee | - |
dc.contributor.author | Kyung Ran Im | - |
dc.contributor.author | Yong Dae Park | - |
dc.contributor.author | N D Sung | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.date.accessioned | 2017-04-19T09:04:04Z | - |
dc.date.available | 2017-04-19T09:04:04Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.29.382 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7284 | - |
dc.description.abstract | Acyl-CoA: cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Pentacyclic triterpenes, ursolic acid (1), oleanolic acid (2), and betulinic acid (3) were isolated from the methanol extracts of the leaves of Lycopus lucidus TURCZ. by bioassay-guided fractionation. The structures of compounds 1-3 were elucidated by their spectroscopic data analysis. Among them, betulinic acid (3) exhibited more potent human ACAT-1 and ACAT-2 inhibitory activities with IC50 values of 16.2±0.6 and 28.8±1.3 μM, respectively. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz. = 택란 잎으로부터 분리한 pentacyclic triterpenes의 사람 ACAT-1과 ACAT-2 저해 활성 | - |
dc.title.alternative | Human ACAT-1 and ACAT-2 inhibitory activity of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz. | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 384 | - |
dc.citation.startPage | 382 | - |
dc.citation.volume | 29 | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.affiliatedAuthor | Kyung Ran Im | - |
dc.contributor.affiliatedAuthor | Yong Dae Park | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 이우송 | - |
dc.contributor.alternativeName | 임경란 | - |
dc.contributor.alternativeName | 박용대 | - |
dc.contributor.alternativeName | 성낙도 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 29, no. 2, pp. 382-384 | - |
dc.identifier.doi | 10.1248/bpb.29.382 | - |
dc.subject.keyword | Acyl-CoA | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Cholesterol acytransferase (ACAT) | - |
dc.subject.keyword | Lycopus lucidus | - |
dc.subject.keyword | Pentacyclic triterpene | - |
dc.subject.local | acyl-CoA | - |
dc.subject.local | Acyl-CoA | - |
dc.subject.local | Acyl CoA | - |
dc.subject.local | acyl CoA | - |
dc.subject.local | atherosclerosis | - |
dc.subject.local | Atherosclerosis | - |
dc.subject.local | atheroclerosis | - |
dc.subject.local | ACAT (acyl-CoA: cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | cholesterol acytransferase (ACAT) | - |
dc.subject.local | Cholestrol Acyl Transferase (ACAT) | - |
dc.subject.local | Acyl CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | ACAT (Acyl-CoA:cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase | - |
dc.subject.local | ACAT | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase | - |
dc.subject.local | acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Cholesterol acytransferase (ACAT) | - |
dc.subject.local | cholestrol acyl transferase (ACAT) | - |
dc.subject.local | Lycopus lucidus | - |
dc.subject.local | Pentacyclic triterpene | - |
dc.description.journalClass | Y | - |
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