Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz. = 택란 잎으로부터 분리한 pentacyclic triterpenes의 사람 ACAT-1과 ACAT-2 저해 활성

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dc.contributor.authorWoo Song Lee-
dc.contributor.authorKyung Ran Im-
dc.contributor.authorYong Dae Park-
dc.contributor.authorN D Sung-
dc.contributor.authorTae Sook Jeong-
dc.date.accessioned2017-04-19T09:04:04Z-
dc.date.available2017-04-19T09:04:04Z-
dc.date.issued2006-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.29.382ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7284-
dc.description.abstractAcyl-CoA: cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Pentacyclic triterpenes, ursolic acid (1), oleanolic acid (2), and betulinic acid (3) were isolated from the methanol extracts of the leaves of Lycopus lucidus TURCZ. by bioassay-guided fractionation. The structures of compounds 1-3 were elucidated by their spectroscopic data analysis. Among them, betulinic acid (3) exhibited more potent human ACAT-1 and ACAT-2 inhibitory activities with IC50 values of 16.2±0.6 and 28.8±1.3 μM, respectively.-
dc.publisherPharmaceutical Soc Japan-
dc.titleHuman ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz. = 택란 잎으로부터 분리한 pentacyclic triterpenes의 사람 ACAT-1과 ACAT-2 저해 활성-
dc.title.alternativeHuman ACAT-1 and ACAT-2 inhibitory activity of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz.-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number2-
dc.citation.endPage384-
dc.citation.startPage382-
dc.citation.volume29-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorKyung Ran Im-
dc.contributor.affiliatedAuthorYong Dae Park-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName임경란-
dc.contributor.alternativeName박용대-
dc.contributor.alternativeName성낙도-
dc.contributor.alternativeName정태숙-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 29, no. 2, pp. 382-384-
dc.identifier.doi10.1248/bpb.29.382-
dc.subject.keywordAcyl-CoA-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordCholesterol acytransferase (ACAT)-
dc.subject.keywordLycopus lucidus-
dc.subject.keywordPentacyclic triterpene-
dc.subject.localacyl-CoA-
dc.subject.localAcyl-CoA-
dc.subject.localAcyl CoA-
dc.subject.localacyl CoA-
dc.subject.localatherosclerosis-
dc.subject.localAtherosclerosis-
dc.subject.localatheroclerosis-
dc.subject.localACAT (acyl-CoA: cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localcholesterol acytransferase (ACAT)-
dc.subject.localCholestrol Acyl Transferase (ACAT)-
dc.subject.localAcyl CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase-
dc.subject.localACAT-
dc.subject.localAcyl-CoA: cholesterol acyltransferase-
dc.subject.localacyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-coenzyme A: cholesterol acyltransferase (ACAT)-
dc.subject.localCholesterol acytransferase (ACAT)-
dc.subject.localcholestrol acyl transferase (ACAT)-
dc.subject.localLycopus lucidus-
dc.subject.localPentacyclic triterpene-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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