DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yong Sam Kim | - |
dc.contributor.author | Hye Yeon Kang | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | S Oh | - |
dc.contributor.author | C H Kim | - |
dc.contributor.author | Chun Jeih Ryu | - |
dc.contributor.author | E Miyoshi | - |
dc.contributor.author | N Taniguchi | - |
dc.contributor.author | Jeong Heon Ko | - |
dc.date.accessioned | 2017-04-19T09:04:05Z | - |
dc.date.available | 2017-04-19T09:04:05Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1615-9853 | - |
dc.identifier.uri | 10.1002/pmic.200500400 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7288 | - |
dc.description.abstract | To gain a better understanding of the mechanism underlying colon cancer and to search for potential markers of colon cancer prognosis, a comparative proteomic analysis of colon cancer WiDr cells was conducted using 2-DE and lectin blot, followed by identification based on ESI-MS. Through these approaches 14 proteins were identified as candidate target proteins for N-acetylglucosaminyl transferase V (GnT-V) that would be expected to be implicated in the progression of colon cancer. We selected protein tyrosine phosphatase kappa (PTPκ) as a model protein to validate this approach to the discovery of novel biomarkers in colon cancer. PTPκ underwent an aberrant glycosylation in GnT-V-overexpressing WiDr cells, and the aberrantly glycosylated PTPκ was vulnerable to proteolytic cleavage. The enhanced cleavage of PTPκ in GnT-V-overexpressing cells was responsible for the mitigation of the homophilic binding capacity, resulting in an increase in cancer cell migration. | - |
dc.publisher | Wiley | - |
dc.title | Identification of target proteins of N-acetylglucosaminyl transferase V in human colon cancer and implications of protein tyrosine phosphatase kappa in enhanced cancer cell migration | - |
dc.title.alternative | Identification of target proteins of N-acetylglucosaminyl transferase V in human colon cancer and implications of protein tyrosine phosphatase kappa in enhanced cancer cell migration | - |
dc.type | Article | - |
dc.citation.title | Proteomics | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 1191 | - |
dc.citation.startPage | 1187 | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Yong Sam Kim | - |
dc.contributor.affiliatedAuthor | Hye Yeon Kang | - |
dc.contributor.affiliatedAuthor | Chun Jeih Ryu | - |
dc.contributor.affiliatedAuthor | Jeong Heon Ko | - |
dc.contributor.alternativeName | 김용삼 | - |
dc.contributor.alternativeName | 강혜연 | - |
dc.contributor.alternativeName | 김진영 | - |
dc.contributor.alternativeName | 오세정 | - |
dc.contributor.alternativeName | 김철호 | - |
dc.contributor.alternativeName | 류춘제 | - |
dc.contributor.alternativeName | Miyoshi | - |
dc.contributor.alternativeName | Taniguchi | - |
dc.contributor.alternativeName | 고정헌 | - |
dc.identifier.bibliographicCitation | Proteomics, vol. 6, no. 4, pp. 1187-1191 | - |
dc.identifier.doi | 10.1002/pmic.200500400 | - |
dc.subject.keyword | 2-DE | - |
dc.subject.keyword | colon cancer | - |
dc.subject.keyword | glycomics | - |
dc.subject.keyword | N-Acetylglucosaminyl transferase V | - |
dc.subject.keyword | protein tyrosine phosphatase κ | - |
dc.subject.local | 2-DE | - |
dc.subject.local | Colon cancer | - |
dc.subject.local | Colon Cancer | - |
dc.subject.local | colon cancer | - |
dc.subject.local | glycomics | - |
dc.subject.local | N-Acetylglucosaminyl transferase V | - |
dc.subject.local | protein tyrosine phosphatase κ | - |
dc.description.journalClass | Y | - |
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