CpG-oligodeoxynucleotide protects immune cells from γ-irradiation- induced cell death

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Title
CpG-oligodeoxynucleotide protects immune cells from γ-irradiation- induced cell death
Author(s)
W J Sohn; K W Lee; S Y Choi; E Chung; Y Lee; T Y Kim; S K Lee; Yong Kyung Choe; J H Lee; D S Kim; H J Kwon
Bibliographic Citation
Molecular Immunology, vol. 43, no. 8, pp. 1163-1171
Publication Year
2006
Abstract
Synthetic oligodeoxynucleotides (CpG-ODNs) and bacterial DNA containing unmethylated CpG dinucleotides in the context of particular base sequences (CpG motifs) are known to inhibit anti-IgM-induced growth arrest and apoptosis of WHEI 231 B lymphocytes, and spontaneous apoptosis of mature spleen B cells in a sequence-specific fashion of the CpG-ODN. Here we report that CpG-ODN protects from the cell death induced by γ-irradiation of primary mouse spleen cells as well as mouse RAW 264.7 macrophage cells and human RPMI 8226 B cells. Experimental results showed that CpG-ODN promotes growth of the cells, and protects the cells from γ-irradiation-induced cell death accompanying Bcl-xS/L and Bcl-2 upregulation. Furthermore, survival of macrophages was enhanced when splenocytes were pretreated with CpG-ODN. Our results suggest the potential application of CpG-ODNs for more efficient cancer radiotherapy by enhancing survival of normal immune cells after radiation damage.
Keyword
γ-IrradiationApoptosisB cellsCpG-ODNMacrophages
ISSN
0161-5890
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.molimm.2005.07.020
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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