Biosynthesis of the heat shock protein 90 inhibitor geldanamycin: new insight into the formation of benzoquinone moiety

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Title
Biosynthesis of the heat shock protein 90 inhibitor geldanamycin: new insight into the formation of benzoquinone moiety
Author(s)
D Lee; Kyeong Lee; X F Cai; N T Dat; S K Boovanahalli; Mijeoung Lee; Jin Chul Shin; Won Cheol Kim; Jae Kap Jeong; Jong Suk Lee; Choong Hwan Lee; Jeong-Hyung Lee; Young-Soo Hong; Jung Joon Lee
Bibliographic Citation
Chembiochem, vol. 7, no. 2, pp. 246-248
Publication Year
2006
Abstract
A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.
Keyword
Antitumor agentsAutooxidationBiosynthesisPolyketides
ISSN
1439-4227
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/cbic.200500441
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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