Enhancement of monascus pigment production by the culture of Monascus sp. J101 at low temperature

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Title
Enhancement of monascus pigment production by the culture of Monascus sp. J101 at low temperature
Author(s)
Jungoh Ahn; Joonki Jung; W Hyung; S Haam; C Shin
Bibliographic Citation
Biotechnology Progress, vol. 22, no. 1, pp. 338-340
Publication Year
2006
Abstract
In general, high broth viscosity is a key factor to be considered in a submerged fermentation of filamentous fungi. High broth viscosity was also observed in a batch fermentation of Monascus sp. J101 at 30°C. In a batch culture at 30°C, most cell growth was accomplished within 48 h, which induced highly entangled clumps. The resultant high viscosity induced heterogeneity inside the fermentor, poor oxygen transfer, and low pigment yield. However, these problems could be overcome by reducing fungal growth rate through culture at low temperature (25°C). Cell growth was moderate and continued for 120 h, and low viscosity was maintained. The DO levels remained at 50% or higher with good mixing. As a result, the pigment yield at 25°C was 10 times greater than at 30°C.
ISSN
8756-7938
Publisher
Wiley
DOI
http://dx.doi.org/10.1021/bp050275o
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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