Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents = 시남알데하이드유도체의 합성 및 항암활성 기전 규명

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dc.contributor.authorDae Seop Shin-
dc.contributor.authorJ H Kim-
dc.contributor.authorSu-Kyung Lee-
dc.contributor.authorDong Cho Han-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorH G Cheon-
dc.contributor.authorK R Kim-
dc.contributor.authorN D Sung-
dc.contributor.authorS J Lee-
dc.contributor.authorS K Kang-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T09:04:11Z-
dc.date.available2017-04-19T09:04:11Z-
dc.date.issued2006-
dc.identifier.issn0968-0896-
dc.identifier.uri10.1016/j.bmc.2005.11.028ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7327-
dc.description.abstractIt has been reported that 2-hydroxycinnamaldehyde and 2-benzoyl- oxycinnamaldehyde inhibited the activity of farnesyl protein transferase, angiogenesis, cell-cell adhesion, and tumor growth in vivo model. In order to improve its anti-tumor activity, dimeric cinnamaldehydes have been synthesized based on 2-hydroxycinnamaldehyde. The synthesized compounds strongly inhibited the growth of human colon tumor cells with GI50 values of 0.6-10 μM. Especially, 2-piperazine derivative blocked in vivo growth of human colon tumor xenograft in nude mice at 10 mg/kg. It was found that their anti-tumor effects induce apoptosis and cell cycle arrest at G2/M phase by the compounds. It was confirmed by detection of apoptosis markers such as activated caspase-3 and cleaved PARP, and cell cycle analysis. The dimeric compounds also inhibited Cdc25B phosphatase which is essential for preinitiating G 2/M transition and S phase progression.-
dc.publisherElsevier-
dc.titleSynthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents = 시남알데하이드유도체의 합성 및 항암활성 기전 규명-
dc.title.alternativeSynthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number8-
dc.citation.endPage2506-
dc.citation.startPage2498-
dc.citation.volume14-
dc.contributor.affiliatedAuthorDae Seop Shin-
dc.contributor.affiliatedAuthorSu-Kyung Lee-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName신대섭-
dc.contributor.alternativeName김종한-
dc.contributor.alternativeName이수경-
dc.contributor.alternativeName한동초-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName천혜경-
dc.contributor.alternativeName김광록-
dc.contributor.alternativeName성낙도-
dc.contributor.alternativeName이승재-
dc.contributor.alternativeName강성권-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 14, no. 8, pp. 2498-2506-
dc.identifier.doi10.1016/j.bmc.2005.11.028-
dc.subject.keywordapoptosis-
dc.subject.keywordCdc25B phosphatase-
dc.subject.keywordcell cycle-
dc.subject.keywordcinnamaldehyde-
dc.subject.keyworddimeric cinnamaldehyde-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localCdc25B phosphatase-
dc.subject.localcell cycle-
dc.subject.localCell cycle-
dc.subject.localCinnamaldehyde-
dc.subject.localcinnamaldehyde-
dc.subject.localdimeric cinnamaldehyde-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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