Development of new natural antioxidants for cosmeceuticals = 천연물 유래 항산화 기능성 화장품 신소재 개발

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Development of new natural antioxidants for cosmeceuticals = 천연물 유래 항산화 기능성 화장품 신소재 개발
Ick Dong Yoo; Jong Pyung Kim; Won Gon Kim; Bong Sik Yun; In Ja Ryoo
Bibliographic Citation
Journal of Society of Cosmetic Scientists of Korea, vol. 31, no. 4, pp. 349-357
Publication Year
New antioxidative substances for cosmeceuticals were screened from natural resources such as microbial metabolites, mushrooms, and medicinal plants. Four antioxidants were isolated from the fungal metabolite of Eupenicillium shearii and their structures were determined to be new phenolic compounds. The compounds were designated as melanocins A, B, C, and D. Melanocins exhibited free radical scavenging activity on DPPH and superoxide with values of , respectively, which were stronger activity than those of and BHA. Melanocin A showed anti-wrinkle effects on the UV-irrated hairless mouse skin. A novel hispidin antioxidative compound designated as inoscavin A was isolated from the fruiting body of the mushroom, Inonotus xeranticus. Inoscavin A scavenged superoxide radical with values of , and inhibited rat liver microsomal lipid peroxidation with values of . Benzastatins , the novel antioxidants isolated from the culture of Streptomyces nitrosporeus showed potent lipid peroxidation inhibitory activity with values of . A cyclopentene compound with strong hypopigmentary effect was isolated from the fungal metabolite of Penicillium sp. and identifed as terrein. Terrein significantly reduced melanin levels in a melanomacyte cell line, Mel-Ab. It showed 10 times stronger activity than kojic acid, but exhibited no cytotoxic effect even in . It was suggested that terrein reduced melanin synthesis by reducing tyrosinase production by MITF down-regulation.
cosmeceuticalsantioxidantsinoscavin Abenzastatinterreinmelanocin
Korea Soc-Assoc-Inst
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Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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