Cosmeceutical properties of levan produced by Zymomonas mobilis

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dc.contributor.authorChul Ho Kim-
dc.date.accessioned2017-04-19T09:04:12Z-
dc.date.available2017-04-19T09:04:12Z-
dc.date.issued2005-
dc.identifier.issn1525-7886-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7332-
dc.description.abstractLevan, a polysaccharide that can be produced by both plants and microorganisms, is a sugar polymer composed of fructose, with β-2,6 linkages. Here, we have attempted to assess the possible use of levan produced by Zymomonas mobilis as a cosmeceutical ingredient. In service of this goal, we assessed a host of levan's properties, including its moisturizing effects, cell cytotoxicity, cell proliferation effects, and anti-inflammation effects. Levan exhibited a moisturizing effect that was almost exactly the same as that evidenced by hyaluronic acid, as well as a similar cell proliferation effect in human fibroblast and keratinocyte cell lines. Moreover, in our cell proliferation test, which was conducted using bio-artificial skin constructed via 3-dimensional (3-D) culture after the induction of primary skin inflammation with 0.05% sodium lauryl sulfate (SLS), cell viability in the presence of levan (0.01 mg/ml, 0.05 mg/ml) was determined to be higher than cell viability in the absence of levan. In our anti-inflammation test, which was also conducted using 3-D artificial skin, and which involved the measurement of a quantity of secreted interleukin-1α (IL-1α), a pre-inflammatory mediator induced by SLS, we determined that the quantity of IL-1α in the 3-D artificial skin treated with 0.01 mg/ml and 0.05 mg/ml of levan was less than that registered in a skin sample that had been treated only with SLS. In this study, we determined that levan exerted an anti-inflammatory effect against inflammatory reactions to skin irritants, and also that levan exerted a cell-proliferative effect in bio-artificial skin, thereby indicating its potential applicability as a cosmeceutical agent.-
dc.publisherSoc Cosmetic Chemists-
dc.titleCosmeceutical properties of levan produced by Zymomonas mobilis-
dc.title.alternativeCosmeceutical properties of levan produced by Zymomonas mobilis-
dc.typeArticle-
dc.citation.titleJournal of Cosmetic Science-
dc.citation.number6-
dc.citation.endPage406-
dc.citation.startPage395-
dc.citation.volume56-
dc.contributor.affiliatedAuthorChul Ho Kim-
dc.contributor.alternativeName김철호-
dc.identifier.bibliographicCitationJournal of Cosmetic Science, vol. 56, no. 6, pp. 395-406-
dc.subject.keywordlevan-
dc.subject.keywordzymomonas-
dc.subject.localLevan-
dc.subject.locallevan-
dc.subject.localzymomonas-
dc.description.journalClassY-
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Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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