Proteomic analysis of pathogenic bacterium Vibrio vulnificus

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Title
Proteomic analysis of pathogenic bacterium Vibrio vulnificus
Author(s)
Ah Young Lee; Sung Goo Park; Mi Jang; S Cho; P K Myung; Y R Kim; J H Rhee; Do Hee Lee; Byoung Chul Park
Bibliographic Citation
Proteomics, vol. 6, no. 4, pp. 1283-1289
Publication Year
2006
Abstract
In this study we have constructed a proteome reference map of the pathogenic bacterium Vibrio vulnificus. From the reference map, we identified several virulence-related proteins, such as ToxR and ToxS, as well as numerous proteins involved in diverse cellular functions. To search for additional virulence-related proteins, we compared the whole proteomes from the wild-type and toxR mutant of V. vulnificus and found that several proteins were up- or down-regulated in the toxR mutant. We suggest that these differentially regulated proteins whose expression is coordinately controlled by a virulence regulator ToxR, some of which are already implicated in virulence, play roles in the pathogenesis of V. vulnificus.
Keyword
2-DEToxRvibrio vulnificusvirulence
ISSN
1615-9853
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/pmic.200500393
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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