Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta

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dc.contributor.authorMi Yeon Chung-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorHye Ran Park-
dc.contributor.authorK Kim-
dc.contributor.authorI A Lee-
dc.contributor.authorD H Kim-
dc.contributor.authorK H Jeune-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorYoung Kook Kim-
dc.date.accessioned2017-04-19T09:04:15Z-
dc.date.available2017-04-19T09:04:15Z-
dc.date.issued2006-
dc.identifier.issn00320943-
dc.identifier.uri10.1055/s-2005-916178ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7350-
dc.description.abstractDuring the screening for diacylglycerol acyltransferase (DGAT) inhibitors from natural products, the lupane-type triterpenoid betulinic acid was isolated from the methanol extract of Alnus hirsuta. It potently inhibited DGAT in the rat liver microsomes with an IC50 value of 9.6 μM. Enzyme kinetic studies showed apparent Km and Ki values of 13.3 μM and 8.1 μM using [14C]oleoyl-CoA as a substrate. A decrease in the apparent Vmax was observed with betulinic acid, whereas the apparent Km remained constant. Therefore, a Lineweaver-Burk plot of DGAT inhibition by betulinic acid showed a non-competitive type of inhibition. In the cell-based assay, betulinic acid inhibited triglyceride (TG) formation by human HepG2 cells. These findings suggest that betulinic acid may be a potential lead compound in the treatment of obesity.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleInhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta-
dc.title.alternativeInhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number3-
dc.citation.endPage269-
dc.citation.startPage267-
dc.citation.volume72-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.alternativeName정미연-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName박혜란-
dc.contributor.alternativeName김관회-
dc.contributor.alternativeName이인아-
dc.contributor.alternativeName김동현-
dc.contributor.alternativeName전경희-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName김영국-
dc.identifier.bibliographicCitationPlanta Medica, vol. 72, no. 3, pp. 267-269-
dc.identifier.doi10.1055/s-2005-916178-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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