Antioxidant effects of quinoline alkaloids and 2,4-Di-tert-butylphenol isolated from Scolopendra subspinipes = 지네로부터 분리한 퀴놀린 알카로이드 및 2,4-디-티부탄올의 항산화 효과

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Title
Antioxidant effects of quinoline alkaloids and 2,4-Di-tert-butylphenol isolated from Scolopendra subspinipes = 지네로부터 분리한 퀴놀린 알카로이드 및 2,4-디-티부탄올의 항산화 효과
Author(s)
Mi-Ae Yoon; Tae Sook JeongDoo Sang Park; M Z Xu; Hyun Woo Oh; K B Song; Woo Song LeeHo Yong Park
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 29, no. 4, pp. 735-739
Publication Year
2006
Abstract
The oxidized low-density lipoprotein (ox-LDL) plays a critical role at the early stages of atherosclerosis. Thus, the prevention of LDL-oxidation by antioxidants may arrest the progression of atherosclerosis. Two quinoline alkaloids, 3,8-dihydroxyquinoline (1) and 2,8-dihydroxy-3,4-dimethoxyquinoline (3), and 2,4-di-tert-butylphenol (2) were isolated from the dried body of Scolopendra subspinipes. Compounds 1-3 exhibited antioxidant activities on copper-mediated (1: IC50=2.6 μM, 2: IC50=8.2 μM, 3: IC50=63.0 μM), AAPH-mediated oxidation (1: IC50=3.9 μM, 2: IC50=9.9 μM, 3: IC50=71.8 μM), and SIN-1-mediated oxidation (1: 70%, 2: 52%, 3: 29% at 5.0 μM) in the TBARS assay. The antioxidant activities of compounds 1-3 were tested with respect to other parameters, such as the lag time of conjugated diene fromation, relative electrophoretic mobility (REM) of ox-LDL, and apoB-100 fragmentation on copper-mediated LDL-oxidation. In addition, compounds 1-3 showed 1,1-diphenyl-2-picrylhydrasyl (DPPH) radical scavenging activity and compound 1 also exhibited metal chelating activity.
Keyword
2,4-di-tert-butyl-phenol3,8-dihydroxyquinolineAntioxidantLow-density lipoprotein (LDL)Scolopendra subspinipes
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.29.735
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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