A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells = Hepatic progenitor 셀에서 유래된 간세포암의 새로운 subtype 동정

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Title
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells = Hepatic progenitor 셀에서 유래된 간세포암의 새로운 subtype 동정
Author(s)
J S Lee; J Heo; L Libbrecht; In-Sun Chu; P Kaposi-Novak; D F Calvisi; A Mikaelyan; L R Roberts; A J Demetris; Z Sun; F Nevens; T Roskams; S S Thorgeirsson
Bibliographic Citation
Nature Medicine, vol. 12, no. 4, pp. 410-416
Publication Year
2006
Abstract
The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests that HCC may comprise several distinct biological phenotypes. These phenotypes may result from activation of different oncogenic pathways during tumorigenesis and/or from a different cell of origin. Here we address whether the transcriptional characteristics of HCC can provide insight into the cellular origin of the tumor. We integrated gene expression data from rat fetal hepatoblasts and adult hepatocytes with HCC from human and mouse models. Individuals with HCC who shared a gene expression pattern with fetal hepatoblasts had a poor prognosis. The gene expression program that distinguished this subtype from other types of HCC included markers of hepatic oval cells, suggesting that HCC of this subtype may arise from hepatic progenitor cells. Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development.
ISSN
1078-8956
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/nm1377
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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