Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda = 대패집나무로부터 분리한 ACAT 저해제

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dc.contributor.authorK R Im-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorN I Baek-
dc.contributor.authorS H Kim-
dc.contributor.authorD K Kim-
dc.date.accessioned2017-04-19T09:04:22Z-
dc.date.available2017-04-19T09:04:22Z-
dc.date.issued2006-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/BF02969391ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7380-
dc.description.abstractTwigs from Ilex macropoda were extracted with MeOH, and the concentrated extracts were partitioned with CH2Cl2, EtOAc, n-BuOH, and H2O. Repeated column chromatography of the CH2Cl 2 fraction ultimately resulted in the isolation of two compounds, via activity-guided fractionation, using ACAT inhibitory activity measurements. According to the physico-chemical data, the chemical structures of these isolated compounds were identified as lupeol (1) and betulin (2). Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 μM, respectively.-
dc.publisherPharmaceutical Soc Korea-
dc.titleAcyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda = 대패집나무로부터 분리한 ACAT 저해제-
dc.title.alternativeAcyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number3-
dc.citation.endPage194-
dc.citation.startPage191-
dc.citation.volume29-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName임경란-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName김성훈-
dc.contributor.alternativeName김대근-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 29, no. 3, pp. 191-194-
dc.identifier.doi10.1007/BF02969391-
dc.subject.keywordACAT inhibitory activity-
dc.subject.keywordBetulin-
dc.subject.keywordIlex macropoda-
dc.subject.keywordLupeol-
dc.subject.localACAT inhibitory activity-
dc.subject.localBetulin-
dc.subject.localIlex macropoda-
dc.subject.localLupeol-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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