Open Access@KRIBBDivision of Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda = 대패집나무로부터 분리한 ACAT 저해제
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- Title
- Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda = 대패집나무로부터 분리한 ACAT 저해제
- Author(s)
- K R Im; Tae Sook Jeong; Byoung-Mog Kwon; N I Baek; S H Kim; D K Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 29, no. 3, pp. 191-194
- Publication Year
- 2006
- Abstract
- Twigs from Ilex macropoda were extracted with MeOH, and the concentrated extracts were partitioned with CH2Cl2, EtOAc, n-BuOH, and H2O. Repeated column chromatography of the CH2Cl 2 fraction ultimately resulted in the isolation of two compounds, via activity-guided fractionation, using ACAT inhibitory activity measurements. According to the physico-chemical data, the chemical structures of these isolated compounds were identified as lupeol (1) and betulin (2). Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 μM, respectively.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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