Comparative genomic organization of the human and bovine PRNP locus

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dc.contributor.authorSang-Haeng Choi-
dc.contributor.authorI C Kim-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorDae-Won Kim-
dc.contributor.authorSung-Hwa Chae-
dc.contributor.authorHan-Ho Choi-
dc.contributor.authorI Choi-
dc.contributor.authorJ S Yeo-
dc.contributor.authorM N Song-
dc.contributor.authorHong-Seog Park-
dc.date.accessioned2017-04-19T09:04:28Z-
dc.date.available2017-04-19T09:04:28Z-
dc.date.issued2006-
dc.identifier.issn08887543-
dc.identifier.uri10.1016/j.ygeno.2005.12.012ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7409-
dc.description.abstractWe sequenced a 208-kb BAC clone spanning the bovine prion protein (PRNP) locus, and compared the genomic structure with that of human. As a result, we determined the precise breakpoint between the two syntenic genomes, located on the 5′ UTR of the PRNP gene, and discovered two highly repetitive sequences near the breakpoint. Further analysis demonstrated that the genomic structure of three genes, PRNP, PRND, and RASSF2, within the syntenic region of the bovine genome is highly conserved in order and orientation. The PRNT locus was not found in bovine but is conserved in several primates, including human. Moreover, we confirmed that the bovine RASSF2 is composed of 10 exons, as is the human gene, showing some difference from a previous report. Our findings may provide useful clues for understanding the evolutional process in the PRNP locus and also the mechanism that allows TSE from cattle to infect humans.-
dc.publisherElsevier-
dc.titleComparative genomic organization of the human and bovine PRNP locus-
dc.title.alternativeComparative genomic organization of the human and bovine PRNP locus-
dc.typeArticle-
dc.citation.titleGenomics-
dc.citation.number5-
dc.citation.endPage607-
dc.citation.startPage598-
dc.citation.volume87-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.alternativeName최상행-
dc.contributor.alternativeName김일철-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName김대원-
dc.contributor.alternativeName채성화-
dc.contributor.alternativeName최한호-
dc.contributor.alternativeName최인호-
dc.contributor.alternativeName여정소-
dc.contributor.alternativeName송미나-
dc.contributor.alternativeName박홍석-
dc.identifier.bibliographicCitationGenomics, vol. 87, no. 5, pp. 598-607-
dc.identifier.doi10.1016/j.ygeno.2005.12.012-
dc.subject.keywordBovine genome-
dc.subject.keywordComparative analysis-
dc.subject.keywordOrganization-
dc.subject.keywordPrion protein-
dc.subject.keywordRepetitive sequence-
dc.subject.keywordSynteny breakpoint-
dc.subject.keywordTransmissible spongiform encephalopathy-
dc.subject.localBovine genome-
dc.subject.localComparative analysis-
dc.subject.localOrganization-
dc.subject.localPrion protein-
dc.subject.localRepetitive sequence-
dc.subject.localSynteny breakpoint-
dc.subject.localTransmissible spongiform encephalopathy-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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