Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma = 긴산꼬리풀에서 추출한 verproside의 알러지성 천식 동물모델 염증

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dc.contributor.authorSei Ryang Oh-
dc.contributor.authorMee Young Lee-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorB Y Park-
dc.contributor.authorOk Kyong Kwon-
dc.contributor.authorHyouk Joung-
dc.contributor.authorJoongku Lee-
dc.contributor.authorDoo-Young Kim-
dc.contributor.authorSangku Lee-
dc.contributor.authorJ H Kim-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T09:04:29Z-
dc.date.available2017-04-19T09:04:29Z-
dc.date.issued2006-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2006.01.010ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7415-
dc.description.abstractAllergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters-such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion-in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.-
dc.publisherElsevier-
dc.titleSuppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma = 긴산꼬리풀에서 추출한 verproside의 알러지성 천식 동물모델 염증-
dc.title.alternativeSuppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number6-
dc.citation.endPage986-
dc.citation.startPage978-
dc.citation.volume6-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorB Y Park-
dc.contributor.affiliatedAuthorOk Kyong Kwon-
dc.contributor.affiliatedAuthorHyouk Joung-
dc.contributor.affiliatedAuthorJoongku Lee-
dc.contributor.affiliatedAuthorDoo-Young Kim-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이미영-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName박보영-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName정혁-
dc.contributor.alternativeName이중구-
dc.contributor.alternativeName김두영-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName김주헌-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 6, no. 6, pp. 978-986-
dc.identifier.doi10.1016/j.intimp.2006.01.010-
dc.subject.keywordallergic asthma-
dc.subject.keywordmouse model-
dc.subject.keywordpseudolysimachion longifolium-
dc.subject.keywordverproside-
dc.subject.localAllergic asthma-
dc.subject.localallergic asthma-
dc.subject.localmouse model-
dc.subject.localMouse model-
dc.subject.localpseudolysimachion longifolium-
dc.subject.localverproside-
dc.subject.localVerproside-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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