Synthesis and cytotoxic activities of 8-alkyl or 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones

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Title
Synthesis and cytotoxic activities of 8-alkyl or 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones
Author(s)
J K Jung; E K Jung; K Nam-Goong; J S Cho; Hwan Mook Kim; Song Kyu Park; Yeong-Ah Yoo; Joo-Hee Kwon; H S Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 29, no. 4, pp. 276-281
Publication Year
2006
Abstract
A series of 8-alkyl- and 8-aryl-8,9-dihydro-7H-isoindolo[5,6- g]quinoxaline-7,9-diones were synthesized using sultine chemistry as a key step in good yield. These compounds were evaluated for their in vitro cytotoxicity against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR).
Keyword
cytotoxic activityisoindoloquinoxalinesynthesis
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02968570
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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