Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | S Y Jeong | - |
| dc.contributor.author | H J Shin | - |
| dc.contributor.author | T S Kim | - |
| dc.contributor.author | H S Lee | - |
| dc.contributor.author | Song Kyu Park | - |
| dc.contributor.author | Hwan Mook Kim | - |
| dc.date.accessioned | 2017-04-19T09:04:39Z | - |
| dc.date.available | 2017-04-19T09:04:39Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.issn | 0021-8820 | - |
| dc.identifier.uri | 10.1038/ja.2006.33 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7434 | - |
| dc.description.abstract | A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi. | - |
| dc.publisher | Springer-Nature Pub Group | - |
| dc.title | Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238 | - |
| dc.title.alternative | Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238 | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Antibiotics | - |
| dc.citation.number | 4 | - |
| dc.citation.endPage | 240 | - |
| dc.citation.startPage | 234 | - |
| dc.citation.volume | 59 | - |
| dc.contributor.affiliatedAuthor | Song Kyu Park | - |
| dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
| dc.contributor.alternativeName | 정성윤 | - |
| dc.contributor.alternativeName | 신희재 | - |
| dc.contributor.alternativeName | 김태식 | - |
| dc.contributor.alternativeName | 이희승 | - |
| dc.contributor.alternativeName | 박성규 | - |
| dc.contributor.alternativeName | 김환묵 | - |
| dc.identifier.bibliographicCitation | Journal of Antibiotics, vol. 59, no. 4, pp. 234-240 | - |
| dc.identifier.doi | 10.1038/ja.2006.33 | - |
| dc.subject.keyword | 16S rDNA | - |
| dc.subject.keyword | 4-acetyl-6-methyl-1-H-pyridine-2-one | - |
| dc.subject.keyword | cytotoxic | - |
| dc.subject.keyword | methylpyridine | - |
| dc.subject.keyword | streptomyces sp. KORDI-3238 | - |
| dc.subject.local | 16S rDNA | - |
| dc.subject.local | 16s rDNA | - |
| dc.subject.local | 4-acetyl-6-methyl-1-H-pyridine-2-one | - |
| dc.subject.local | Cytotoxic | - |
| dc.subject.local | cytotoxic | - |
| dc.subject.local | methylpyridine | - |
| dc.subject.local | streptomyces sp. KORDI-3238 | - |
| dc.description.journalClass | Y | - |
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