Role of E2F1 in endoplasmic reticulum stress signaling

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dc.contributor.authorKyung Mi Park-
dc.contributor.authorDong Joon Kim-
dc.contributor.authorSang Gi Paik-
dc.contributor.authorSoo Jung Kim-
dc.contributor.authorYoung Il Yeom-
dc.date.accessioned2017-04-19T09:04:44Z-
dc.date.available2017-04-19T09:04:44Z-
dc.date.issued2006-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7458-
dc.description.abstractThe transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that E2Fl-/- murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor 2α (eIF2α). These results therefore indicate that E2F1 deficiency increases phosphorylation of eIF2α in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis. in E2F1 deficient cells is related to the high level of eIF2α phosphorylation.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRole of E2F1 in endoplasmic reticulum stress signaling-
dc.title.alternativeRole of E2F1 in endoplasmic reticulum stress signaling-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number3-
dc.citation.endPage359-
dc.citation.startPage356-
dc.citation.volume21-
dc.contributor.affiliatedAuthorKyung Mi Park-
dc.contributor.affiliatedAuthorDong Joon Kim-
dc.contributor.affiliatedAuthorSang Gi Paik-
dc.contributor.affiliatedAuthorSoo Jung Kim-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeName박경미-
dc.contributor.alternativeName김동준-
dc.contributor.alternativeName백상기-
dc.contributor.alternativeName김수정-
dc.contributor.alternativeName염영일-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 21, no. 3, pp. 356-359-
dc.subject.keywordE2F1-
dc.subject.keywordendoplasmic reticulum stress-
dc.subject.keywordeukaryotic translation initiation factor 2α (eIF2α)-
dc.subject.keywordthapsigargin-
dc.subject.localE2F1-
dc.subject.localEndoplasmic reticulum (ER) stress-
dc.subject.localendoplasmic reticulum stress-
dc.subject.localendoplasmic reticulum-stress-
dc.subject.localEndoplasmic reticulum stress-
dc.subject.localeukaryotic translation initiation factor 2α (eIF2α)-
dc.subject.localThapsigargin-
dc.subject.localthapsigargin-
dc.description.journalClassY-
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Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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