Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel δ-lactam-based histone deacetylase (HDAC) inhibitors

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dc.contributor.authorHwan Mook Kim-
dc.contributor.authorKiho Lee-
dc.contributor.authorB W Park-
dc.contributor.authorDong Kyu Ryu-
dc.contributor.authorKangjeon Kim-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorJ W Han-
dc.contributor.authorH Y Lee-
dc.contributor.authorH Y Lee-
dc.contributor.authorG Han-
dc.date.accessioned2017-04-19T09:04:45Z-
dc.date.available2017-04-19T09:04:45Z-
dc.date.issued2006-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2006.04.091ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7461-
dc.description.abstractδ-Lactam-based hydroxamic acids, inhibitors of histone deacetylase (HDAC), have been synthesized via ring closure metathesis of key diene intermediates followed by conversion to hydroxamic acid analogues. The hydroxamic acids 12a, 12b, and 17c showed potent inhibitory activity in HDAC enzyme assay. The hydroxamic acid 12b exhibited growth inhibitory activity on five human tumor cell lines, showing good sensitivity on the MDA-MB-231 breast tumor cell.-
dc.publisherElsevier-
dc.titleSynthesis, enzymatic inhibition, and cancer cell growth inhibition of novel δ-lactam-based histone deacetylase (HDAC) inhibitors-
dc.title.alternativeSynthesis, enzymatic inhibition, and cancer cell growth inhibition of novel δ-lactam-based histone deacetylase (HDAC) inhibitors-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number15-
dc.citation.endPage4070-
dc.citation.startPage4068-
dc.citation.volume16-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.affiliatedAuthorKiho Lee-
dc.contributor.affiliatedAuthorDong Kyu Ryu-
dc.contributor.affiliatedAuthorKangjeon Kim-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorSong Kyu Park-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName박범우-
dc.contributor.alternativeName류동규-
dc.contributor.alternativeName김강전-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName한정환-
dc.contributor.alternativeName이희윤-
dc.contributor.alternativeName이현용-
dc.contributor.alternativeName한균희-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 16, no. 15, pp. 4068-4070-
dc.identifier.doi10.1016/j.bmcl.2006.04.091-
dc.subject.keywordδ-Lactam-
dc.subject.keywordanticancer-
dc.subject.keywordhistone deacetylase-
dc.subject.keywordring closure metathesis-
dc.subject.localδ-Lactam-
dc.subject.localAnti-cancer-
dc.subject.localAnticancer-
dc.subject.localanti-cancer-
dc.subject.localanticancer-
dc.subject.localAnti-Cancer-
dc.subject.localHistone deacetylase-
dc.subject.localhistone deacetylase (HDAC)-
dc.subject.localHistone deacetylases-
dc.subject.localhistone deacetylase-
dc.subject.localring closure metathesis-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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