DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwan Mook Kim | - |
dc.contributor.author | Kiho Lee | - |
dc.contributor.author | B W Park | - |
dc.contributor.author | Dong Kyu Ryu | - |
dc.contributor.author | Kangjeon Kim | - |
dc.contributor.author | Chang Woo Lee | - |
dc.contributor.author | Song Kyu Park | - |
dc.contributor.author | J W Han | - |
dc.contributor.author | H Y Lee | - |
dc.contributor.author | H Y Lee | - |
dc.contributor.author | G Han | - |
dc.date.accessioned | 2017-04-19T09:04:45Z | - |
dc.date.available | 2017-04-19T09:04:45Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2006.04.091 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7461 | - |
dc.description.abstract | δ-Lactam-based hydroxamic acids, inhibitors of histone deacetylase (HDAC), have been synthesized via ring closure metathesis of key diene intermediates followed by conversion to hydroxamic acid analogues. The hydroxamic acids 12a, 12b, and 17c showed potent inhibitory activity in HDAC enzyme assay. The hydroxamic acid 12b exhibited growth inhibitory activity on five human tumor cell lines, showing good sensitivity on the MDA-MB-231 breast tumor cell. | - |
dc.publisher | Elsevier | - |
dc.title | Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel δ-lactam-based histone deacetylase (HDAC) inhibitors | - |
dc.title.alternative | Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel δ-lactam-based histone deacetylase (HDAC) inhibitors | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 15 | - |
dc.citation.endPage | 4070 | - |
dc.citation.startPage | 4068 | - |
dc.citation.volume | 16 | - |
dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
dc.contributor.affiliatedAuthor | Kiho Lee | - |
dc.contributor.affiliatedAuthor | Dong Kyu Ryu | - |
dc.contributor.affiliatedAuthor | Kangjeon Kim | - |
dc.contributor.affiliatedAuthor | Chang Woo Lee | - |
dc.contributor.affiliatedAuthor | Song Kyu Park | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.contributor.alternativeName | 이기호 | - |
dc.contributor.alternativeName | 박범우 | - |
dc.contributor.alternativeName | 류동규 | - |
dc.contributor.alternativeName | 김강전 | - |
dc.contributor.alternativeName | 이창우 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 한정환 | - |
dc.contributor.alternativeName | 이희윤 | - |
dc.contributor.alternativeName | 이현용 | - |
dc.contributor.alternativeName | 한균희 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 15, pp. 4068-4070 | - |
dc.identifier.doi | 10.1016/j.bmcl.2006.04.091 | - |
dc.subject.keyword | δ-Lactam | - |
dc.subject.keyword | anticancer | - |
dc.subject.keyword | histone deacetylase | - |
dc.subject.keyword | ring closure metathesis | - |
dc.subject.local | δ-Lactam | - |
dc.subject.local | Anti-cancer | - |
dc.subject.local | Anticancer | - |
dc.subject.local | anti-cancer | - |
dc.subject.local | anticancer | - |
dc.subject.local | Anti-Cancer | - |
dc.subject.local | Histone deacetylase | - |
dc.subject.local | histone deacetylase (HDAC) | - |
dc.subject.local | Histone deacetylases | - |
dc.subject.local | histone deacetylase | - |
dc.subject.local | ring closure metathesis | - |
dc.description.journalClass | Y | - |
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