Highly diastereoselective epimerization: stereodivergent synthesis of α-hydroxy-β-amino isopentanoic acid = 알파-히드록시-베타-아미노 이소펜탄오익 에시드의 입체선택적인 합성

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dc.contributor.authorW D Seo-
dc.contributor.authorM J Curtis-Long-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorJ H Lee-
dc.contributor.authorM S Yang-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorK H Park-
dc.date.accessioned2017-04-19T09:04:45Z-
dc.date.available2017-04-19T09:04:45Z-
dc.date.issued2006-
dc.identifier.issn0022-3263-
dc.identifier.uri10.1021/jo060309mko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7465-
dc.description.abstractThe high diastereoselectivity of the base-catalyzed epimerization of oxazolidin-2-ones 7 and 8 is shown to depend on the nature of the N-substituent (R group); when R = Bn, the 4,5-trans-product (4S,5R)-9 is formed, whereas when R = H the 4,5-cis-product (45,55)-10 is formed, both with >99:1 dr. The successful hydrolysis of the oxazolidin-2-one group in both cis- and trans-derivatives show this to be a stereodivergent route to enantiopure α-hydroxy-β-amino isopentanoic acids (2R,3S)-1 and (25,35)-2.-
dc.publisherAmer Chem Soc-
dc.titleHighly diastereoselective epimerization: stereodivergent synthesis of α-hydroxy-β-amino isopentanoic acid = 알파-히드록시-베타-아미노 이소펜탄오익 에시드의 입체선택적인 합성-
dc.title.alternativeHighly diastereoselective epimerization: stereodivergent synthesis of α-hydroxy-β-amino isopentanoic acid-
dc.typeArticle-
dc.citation.titleJournal of Organic Chemistry-
dc.citation.number13-
dc.citation.endPage5011-
dc.citation.startPage5008-
dc.citation.volume71-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName서우덕-
dc.contributor.alternativeNameCurtis-Long-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName이진환-
dc.contributor.alternativeName양민석-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName박기훈-
dc.identifier.bibliographicCitationJournal of Organic Chemistry, vol. 71, no. 13, pp. 5008-5011-
dc.identifier.doi10.1021/jo060309m-
dc.description.journalClassY-
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Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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