Expression of hepatitis C virus nonstructural 4B in transgenic mice

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Title
Expression of hepatitis C virus nonstructural 4B in transgenic mice
Author(s)
A G Wang; H B Moon; J M Kim; S B Hwang; Dae Yeul Yu; Dong Seok Lee
Bibliographic Citation
Experimental and Molecular Medicine, vol. 38, no. 3, pp. 241-246
Publication Year
2006
Abstract
Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential causative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenotypically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.
Keyword
hepaciviruslivermice, transgenicNs4 protein, hepatitis C virusviral nonstructural proteins
ISSN
I000-0028
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/emm.2006.29
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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