Two novel furan derivatives from Phellinus linteus with anti-complement activity = 항보체효과를 갖는 상황버섯의 퓨란화합물

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Title
Two novel furan derivatives from Phellinus linteus with anti-complement activity = 항보체효과를 갖는 상황버섯의 퓨란화합물
Author(s)
B S Min; Bong Sik Yun; Hyeong Kyu Lee; H J Jung; H A Jung; J S Choi
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 12, pp. 3255-3257
Publication Year
2006
Abstract
Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC50 values of 33.6 and 33.7 μM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.
Keyword
anti-complement activityfuran derivativesphellinus linteusstructural determination
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2006.03.027
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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