Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis

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dc.contributor.authorP T Thuong-
dc.contributor.authorB S Min-
dc.contributor.authorW Y Jin-
dc.contributor.authorM K Na-
dc.contributor.authorJ P Lee-
dc.contributor.authorR S Seong-
dc.contributor.authorY M Lee-
dc.contributor.authorK S Song-
dc.contributor.authorY H Seong-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorK H Bae-
dc.contributor.authorS S Kang-
dc.date.accessioned2017-04-19T09:04:47Z-
dc.date.available2017-04-19T09:04:47Z-
dc.date.issued2006-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.29.830ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7471-
dc.description.abstractA new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1β,2α,3α,23-tetrahydroxyurs-12- en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. of these, compounds 1 - 2 and 4 - 8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 μM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.-
dc.publisherPharmaceutical Soc Japan-
dc.titleAnti-complementary activity of ursane-type triterpenoids from Weigela subsessilis-
dc.title.alternativeAnti-complementary activity of ursane-type triterpenoids from Weigela subsessilis-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number4-
dc.citation.endPage833-
dc.citation.startPage830-
dc.citation.volume29-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeNameThuong-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName이종필-
dc.contributor.alternativeName성락선-
dc.contributor.alternativeName이영미-
dc.contributor.alternativeName송경식-
dc.contributor.alternativeName성연희-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName강삼식-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 29, no. 4, pp. 830-833-
dc.identifier.doi10.1248/bpb.29.830-
dc.subject.keywordAnti-complementary-
dc.subject.keywordCaprifoliaceae-
dc.subject.keywordUrsane-type triterpenoid-
dc.subject.keywordWeigela subsessilis-
dc.subject.keywordWeigelic acid-
dc.subject.localanticomplementary-
dc.subject.localAnti-complementary-
dc.subject.localCaprifoliaceae-
dc.subject.localcaprifoliaceae-
dc.subject.localUrsane-type triterpenoid-
dc.subject.localWeigela subsessilis-
dc.subject.localWeigelic acid-
dc.description.journalClassY-
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