DC Field | Value | Language |
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dc.contributor.author | P T Thuong | - |
dc.contributor.author | B S Min | - |
dc.contributor.author | W Y Jin | - |
dc.contributor.author | M K Na | - |
dc.contributor.author | J P Lee | - |
dc.contributor.author | R S Seong | - |
dc.contributor.author | Y M Lee | - |
dc.contributor.author | K S Song | - |
dc.contributor.author | Y H Seong | - |
dc.contributor.author | Hyeong Kyu Lee | - |
dc.contributor.author | K H Bae | - |
dc.contributor.author | S S Kang | - |
dc.date.accessioned | 2017-04-19T09:04:47Z | - |
dc.date.available | 2017-04-19T09:04:47Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.29.830 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7471 | - |
dc.description.abstract | A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1β,2α,3α,23-tetrahydroxyurs-12- en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. of these, compounds 1 - 2 and 4 - 8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 μM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis | - |
dc.title.alternative | Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 833 | - |
dc.citation.startPage | 830 | - |
dc.citation.volume | 29 | - |
dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
dc.contributor.alternativeName | Thuong | - |
dc.contributor.alternativeName | 민병선 | - |
dc.contributor.alternativeName | Jin | - |
dc.contributor.alternativeName | 나민균 | - |
dc.contributor.alternativeName | 이종필 | - |
dc.contributor.alternativeName | 성락선 | - |
dc.contributor.alternativeName | 이영미 | - |
dc.contributor.alternativeName | 송경식 | - |
dc.contributor.alternativeName | 성연희 | - |
dc.contributor.alternativeName | 이형규 | - |
dc.contributor.alternativeName | 배기환 | - |
dc.contributor.alternativeName | 강삼식 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 29, no. 4, pp. 830-833 | - |
dc.identifier.doi | 10.1248/bpb.29.830 | - |
dc.subject.keyword | Anti-complementary | - |
dc.subject.keyword | Caprifoliaceae | - |
dc.subject.keyword | Ursane-type triterpenoid | - |
dc.subject.keyword | Weigela subsessilis | - |
dc.subject.keyword | Weigelic acid | - |
dc.subject.local | anticomplementary | - |
dc.subject.local | Anti-complementary | - |
dc.subject.local | Caprifoliaceae | - |
dc.subject.local | caprifoliaceae | - |
dc.subject.local | Ursane-type triterpenoid | - |
dc.subject.local | Weigela subsessilis | - |
dc.subject.local | Weigelic acid | - |
dc.description.journalClass | Y | - |
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