DC Field | Value | Language |
---|---|---|
dc.contributor.author | S L Choi | - |
dc.contributor.author | Y S Choi | - |
dc.contributor.author | Y K Kim | - |
dc.contributor.author | N D Sung | - |
dc.contributor.author | Chang-Won Kho | - |
dc.contributor.author | Byoung Chul Park | - |
dc.contributor.author | Eun-Mi Kim | - |
dc.contributor.author | Jeong-Hyung Lee | - |
dc.contributor.author | K M Kim | - |
dc.contributor.author | M Y Kim | - |
dc.contributor.author | P K Myung | - |
dc.date.accessioned | 2017-04-19T09:04:48Z | - |
dc.date.available | 2017-04-19T09:04:48Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/BF02969398 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7477 | - |
dc.description.abstract | We employed human SK-MEL-28 cells as a model system to identify cellular proteins that accompany N-(4-methyl)phenyl-O-(4-methoxy)phenyl-thionocarbamate (MMTC)-induced apoptosis based on a proteomic approach. Cell viability tests revealed that SK-MEL-28 skin cancer cells underwent more cell death than normal HaCaT cells in a dose-dependent manner after treatment with MMTC. Two-dimensional electrophoresis in conjunction with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC-induced apoptosis is accompanied by increased levels of caspase-1, checkpoint suppressor-1, caspase-4, NF-κB inhibitor, AP-2, c-Jun-N-terminal kinase, melanoma inhibitor, granzyme K, G1/S specific cyclin D3, cystein rich protein, Ras-related protein Rab-37 or Ras-related protein Rab-13, and reduced levels of EMS (oncogene), ATP synthase, tyrosine-phosphatase, Cdc25c, 14-3-3 protein or specific structure of nuclear receptor. The migration suppressing effect of MMTC on SK-MEL-28 cell was tested. MMTC suppressed the metastasis of SK-MEL-8 cells. It was also identified that MMTC had little angiogenic effect because it did not suppress the proliferation of HUVEC cell line. These results suggest that MMTC is a novel chemotherapeutic and metastatic agents against the SK-MEL-28 human melanoma cell line. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells | - |
dc.title.alternative | Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbarmate-induced apoptosis in human melanoma SK-MEL-28 cells | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 234 | - |
dc.citation.startPage | 224 | - |
dc.citation.volume | 29 | - |
dc.contributor.affiliatedAuthor | Chang-Won Kho | - |
dc.contributor.affiliatedAuthor | Byoung Chul Park | - |
dc.contributor.affiliatedAuthor | Eun-Mi Kim | - |
dc.contributor.affiliatedAuthor | Jeong-Hyung Lee | - |
dc.contributor.alternativeName | 최수라 | - |
dc.contributor.alternativeName | 최윤실 | - |
dc.contributor.alternativeName | 김영관 | - |
dc.contributor.alternativeName | 성낙도 | - |
dc.contributor.alternativeName | 고창원 | - |
dc.contributor.alternativeName | 박병철 | - |
dc.contributor.alternativeName | 김은미 | - |
dc.contributor.alternativeName | 이정형 | - |
dc.contributor.alternativeName | 김경미 | - |
dc.contributor.alternativeName | 김민영 | - |
dc.contributor.alternativeName | 명평근 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 29, no. 3, pp. 224-234 | - |
dc.identifier.doi | 10.1007/BF02969398 | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | metastasis | - |
dc.subject.keyword | N-(4-methyl)phenyl-O-(4-methoxy)phenyl- thionocarbamate | - |
dc.subject.keyword | proteome map | - |
dc.subject.keyword | SK-MEL-26 cells | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.subject.local | metastasis | - |
dc.subject.local | Metastasis | - |
dc.subject.local | N-(4-methyl)phenyl-O-(4-methoxy)phenyl- thionocarbamate | - |
dc.subject.local | proteome map | - |
dc.subject.local | SK-MEL-26 cells | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.