Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

Cited 58 time in scopus
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Title
Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue
Author(s)
K Y Kim; H Y Kim; J H Kim; Chul Ho Lee; D H Kim; Y H Lee; S H Han; J S Lim; D H Cho; M S Lee; S Yoon; K I Kim; D Y Yoon; Y Yang
Bibliographic Citation
FEBS Letters, vol. 580, no. 16, pp. 3953-3960
Publication Year
2006
Abstract
CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.
Keyword
adipokineCTRPproinflammatory cytokines
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2006.06.034
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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