Hepatocellular carcinoma model cell lines with two distinct migration modes

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dc.contributor.authorI J Lee-
dc.contributor.authorZ S Li-
dc.contributor.authorY N Lee-
dc.contributor.authorX J Jin-
dc.contributor.authorJeong-Hyung Lee-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorNam-Soon Kim-
dc.contributor.authorDong Chul Lee-
dc.contributor.authorHeun-Sik Lee-
dc.contributor.authorS J Yang-
dc.contributor.authorSoo Jung Kim-
dc.contributor.authorYoung Il Yeom-
dc.date.accessioned2017-04-19T09:04:50Z-
dc.date.available2017-04-19T09:04:50Z-
dc.date.issued2006-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2006.06.030ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7486-
dc.description.abstractMigration is an essential feature of metastatic cancer cells. To understand how motility is regulated in hepatocellular carcinoma, we analyzed gene expression profiles of mouse model cell lines we established from transgenic mice carrying SV40 large T antigen. A non-motile HC9 cell line was isolated from mouse liver tumors, and two additional cell lines, HCM1 and HCM4, were derived from HC9 cells. We found that both HCM1 and HCM4 cells were substantially more migratory than HC9, and that HCM1 generated tumor nodules in nude mice. In contrast to HCM4 cells that exhibited mesenchymal cell-type gene expression similar to HC9 cells, HCM1 cells appeared to have undergone a mesenchymal-amoeboidal transition. Thus, HCM1 and HCM4 cells have distinct migration and gene expression patterns, and together with HC9 cells, they can serve as model cell lines for understanding how migration is acquired and controlled in hepatocellular carcinoma.-
dc.publisherElsevier-
dc.titleHepatocellular carcinoma model cell lines with two distinct migration modes-
dc.title.alternativeHepatocellular carcinoma model cell lines with two distinct migration modes-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number4-
dc.citation.endPage1227-
dc.citation.startPage1217-
dc.citation.volume346-
dc.contributor.affiliatedAuthorJeong-Hyung Lee-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.affiliatedAuthorNam-Soon Kim-
dc.contributor.affiliatedAuthorDong Chul Lee-
dc.contributor.affiliatedAuthorHeun-Sik Lee-
dc.contributor.affiliatedAuthorSoo Jung Kim-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeName이인정-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName이영남-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName이정형-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName김남순-
dc.contributor.alternativeName이동철-
dc.contributor.alternativeName이헌식-
dc.contributor.alternativeName양석진-
dc.contributor.alternativeName김수정-
dc.contributor.alternativeName염영일-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 346, no. 4, pp. 1217-1227-
dc.identifier.doi10.1016/j.bbrc.2006.06.030-
dc.subject.keywordGene expression profiles-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordMesenchymal-
dc.subject.keywordMesenchymal-amoeboidal transition-
dc.subject.keywordMigration-
dc.subject.localGene expression profiles-
dc.subject.localgene expression profile-
dc.subject.localGene expression profile-
dc.subject.localHepatocellular carcinomas-
dc.subject.localHepatocellular carcinoma (HCC)-
dc.subject.localHepatocellular carcinoma-
dc.subject.localhepatocellular carcinoma (HCC)-
dc.subject.localhepatocellular carcinoma-
dc.subject.localMesenchymal-
dc.subject.localMesenchymal-amoeboidal transition-
dc.subject.localMigration-
dc.subject.localmigration-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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