Gold-conjugated protein nanoarrays through block-copolymer lithography: from fabrication to biosensor design

Cited 37 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJ M Jung-
dc.contributor.authorK Y Kwon-
dc.contributor.authorTai-Hwan Ha-
dc.contributor.authorBong Hyun Chung-
dc.contributor.authorH T Jung-
dc.date.accessioned2017-04-19T09:04:52Z-
dc.date.available2017-04-19T09:04:52Z-
dc.date.issued2006-
dc.identifier.issn16136810-
dc.identifier.uri10.1002/smll.200600005ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7495-
dc.description.abstractA method to immobilize proteins at predefined position using gold-conjugated protein nanoarrays was investigated. Two different proteins, gold nanoparticle-conjugated streptavidin and gold-conjugated protein G molecules were selected as model proteins in the study. The individual protein molecules are immobilized and stabilized with inherent spacing without interfering with the intermolecular interactions. The electrochemical behavior of the exposed gold film was studied as a function of the RIE time to verify whether the ordered pore region is exposed to the underlying surface, which is critical for the immobilization of probe biomolecules. The selective deposition of SA-AuNPs on the biotin-modified surface was further supported by CV analysis, where the voltammetric peak current associated with the redox pair became substantially lower as the surface became blocked by adsorbed streptavidin molecule. This method provides a promising tool for biosensor applications.-
dc.publisherWiley-
dc.titleGold-conjugated protein nanoarrays through block-copolymer lithography: from fabrication to biosensor design-
dc.title.alternativeGold-conjugated protein nanoarrays through block-copolymer lithography: from fabrication to biosensor design-
dc.typeArticle-
dc.citation.titleSmall-
dc.citation.number8-
dc.citation.endPage1015-
dc.citation.startPage1010-
dc.citation.volume2-
dc.contributor.affiliatedAuthorTai-Hwan Ha-
dc.contributor.alternativeName정진미-
dc.contributor.alternativeName권기영-
dc.contributor.alternativeName하태환-
dc.contributor.alternativeName정봉현-
dc.contributor.alternativeName정희태-
dc.identifier.bibliographicCitationSmall, vol. 2, no. 8, pp. 1010-1015-
dc.identifier.doi10.1002/smll.200600005-
dc.subject.keywordBiosensors-
dc.subject.keywordBlock copolymers-
dc.subject.keywordLithography-
dc.subject.keywordNanoparticles-
dc.subject.keywordProteins-
dc.subject.localBiosensors-
dc.subject.localBiosensor-
dc.subject.localBlock copolymers-
dc.subject.localBlock copolymer-
dc.subject.localLithography-
dc.subject.localNanoparticles-
dc.subject.localNanoparticle-
dc.subject.localProteins-
dc.subject.localProtein-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.