Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis
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- Title
- Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis
- Author(s)
- Jung-Sung Yoo; C J Zheng; Sangku Lee; J H Kim; Won Gon Kim
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 18, pp. 4889-4892
- Publication Year
- 2006
- Abstract
- A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 μM and also showed antibacterial activity against Escherichia coli and S. aureus.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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