Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis

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Title
Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis
Author(s)
Jung-Sung Yoo; C J Zheng; Sangku Lee; J H Kim; Won Gon Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 18, pp. 4889-4892
Publication Year
2006
Abstract
A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 μM and also showed antibacterial activity against Escherichia coli and S. aureus.
Keyword
AntibacterialMacrolactinPeptide deformylaseS. aureus
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2006.06.058
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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