Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma

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Title
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma
Author(s)
Min Kyun Na; JunPil Jang; B S Min; S J Lee; M S Lee; Bo Yeon Kim; Won Keun Oh; Jong Seog Ahn
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 18, pp. 4738-4742
Publication Year
2006
Abstract
Fatty acid synthase (FAS) is emerging as a potential therapeutic target to treat cancer and obesity. Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma (Dryopteridaceae), using an in vitro FAS inhibitory assay, resulted in the isolation of a series of acylphloroglucinols, as the active principles. The isolates 1-10 inhibited FAS with IC50 values ranging from 23.1 ± 1.4 to 71.7 ± 3.9 μM. The results of the present study indicate that the acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors.
Keyword
Fatty acid synthase (FAS)DryopteridaceaeDryopteris crassirhizomaFAS inhibitorsAcylphloroglucinols
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2006.07.018
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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