Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents

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Title
Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents
Author(s)
Ki Duk Park; J H Lee; S H Kim; Tae Hoon Kang; Jae Sun Moon; Sung Uk Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 15, pp. 3913-3916
Publication Year
2006
Abstract
By introducing various aromatic groups in 13-C of berberine and berberrubine, a series of 13-(substituted benzyl) berberine and berberrubine derivatives were synthesized and examined for antifungal activities against various human pathogenic fungi. The synthesized compounds exhibited more potent antifungal activities than berberine and berberrubine. Among them, 13-(4-isopropyl benzyl) berberine (6e) exerted the most potent antifungal activities against Candida species (MIC = 1-8 μg/ml) and a 4-fold stronger activity than 13-(4-isopropyl benzyl) berberrubine (7e) synthesized by pyrolysis of compound 6e.
Keyword
13-(Substituted benzyl) berberine13-(Substituted benzyl) berberrubineantifungal activity
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2006.05.033
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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