Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity =원화의 flavonoids, biscoumarin, amide 분리와 항보체 활성

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Title
Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity =원화의 flavonoids, biscoumarin, amide 분리와 항보체 활성
Author(s)
Bo-Young Park; B S Min; Sei Ryang OhJung Hee Kim; K H Bae; Hyeong Kyu Lee
Bibliographic Citation
Phytotherapy Research, vol. 20, no. 7, pp. 610-613
Publication Year
2006
Abstract
As part of an ongoing study aimed at identifying the anti-complement active compound from the flower buds of Daphne genkwa, ten flavonoids, one biscoumarin and one amide were isolated. Their structures were identified from spectroscopic and physicochemical data as genkwanin 5-O-β-D-primveroside (1), apigenin 7-O-β-D-glucuronide (2), genkwanin 5-O-β-D- glucopyranoside (3), apigenin 5-O-β-D-glucopyranoside (4), genkwanin (5), apigenin (6), luteolin 7-methyl ether (7), luteolin (8), daphnoretin (9), velutin (10), 7-methoxyacacetin (11) and aurantiamide acetate (12). Among them, compounds 9, 10 and 12 were isolated from this plant for the first time. The anti-complement activity of these compounds was tested against the classical pathway of the complement system. Among the compounds, daphnoretin (9) exhibited significant anti-complement activity with an IC50 value of 11.4 μM, whereas the other compounds were not active in the assay.
Keyword
Anti-complement activityDaphne genkwaDaphnoretin
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.1915
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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