Indenone derivatives: A novel template for peroxisome proliferator- activated receptor γ (PPARγ) agonists
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- Title
- Indenone derivatives: A novel template for peroxisome proliferator- activated receptor γ (PPARγ) agonists
- Author(s)
- J H Ahn; M S Shin; S H Jung; S K Kang; K R Kim; S D Rhee; W H Jung; S D Yang; Seung Jun Kim; J R Woo; Jeong-Hyung Lee; H G Cheon; S S Kim
- Bibliographic Citation
- Journal of Medicinal Chemistry, vol. 49, no. 15, pp. 4781-4784
- Publication Year
- 2006
- Abstract
- Agonists of peroxisome proliferator-activated receptor γ(PPAR γ) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR γ agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC 50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
- ISSN
- 0022-2623
- Publisher
- Amer Chem Soc
- Full Text Link
- http://dx.doi.org/10.1021/jm060389m
- Type
- Article
- Appears in Collections:
- Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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