Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans

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Title
Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans
Author(s)
S Yang; Min Kyun Na; Jun Pil Jang; Kyung Ah Kim; Bo Yeon Kim; N J Sung; Won Keun Oh; Jong Seog Ahn
Bibliographic Citation
Phytotherapy Research, vol. 20, no. 8, pp. 680-682
Publication Year
2006
Abstract
Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as one of the drug targets for treating type 2 diabetes and obesity. Bioassay-guided fractionation of a MeOH extract of the semen of Myristica fragrans Houtt. (Myristicaceae) afforded PTP1B inhibitory compounds, meso-dihydroguaiaretic acid (1) and otobaphenol (2). Compounds 1 and 2 inhibited PTP1B with IC50 values of 19.6 ± 03 and 48.9 ± 0.5 μM, respectively, in the manner of non-competitive inhibitors. Treatment with compound 1 on 32D cells overexpressing the insulin receptor (IR) resulted in a dose-dependent increase in the tyrosine phosphorylation of IR. These results indicate that compound 1 can act as an enhancing agent in intracellular insulin signaling, possibly through the inhibition of PTP1B activity.
Keyword
meso-dihydroguaiaretic acidMyristica fragransOtobaphenolPTP1BType 2 diabetes
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.1935
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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