Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells

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Title
Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells
Author(s)
X F Cai; X Jin; D Lee; Y T Yang; Kyeong Lee; Young-Soo Hong; J H Lee; Jung Joon Lee
Bibliographic Citation
Journal of Natural Products, vol. 69, no. 7, pp. 1095-1097
Publication Year
2006
Abstract
A bioassay-guided phytochemical investigation on the methanol extract of Boehmeria pannosa, using a HIF-1-mediated reporter gene assay, led to the isolation of two phenanthroquinolizidine alkaloids, (-)-cryptopleurine (1) and (-)-(15R)-hydroxycryptopleurine (2). The structure of the new compound 2 was determined by spectroscopic methods. Compounds 1 and 2 potently inhibited the hypoxia-induced expression of a reporter gene under the control of a hypoxia response element (HRE) with IC50 values of 8.7 and 48.1 nM, respectively. Furthermore, 1 and 2 suppressed the accumulation of HEF-1α protein in a dose-dependent manner, but not the HIF-1β protein and inhibited expression of vascular endothelial growth factor (VEGF) by hypoxia.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np060081y
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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