Anti-atherosclerotic effect of a new synthetic functional oil containing mono-and diacylglycerol from corn oil

Cited 5 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorK H Cho-
dc.contributor.authorJong Min Han-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorJ H Lee-
dc.contributor.authorJ H Lee-
dc.contributor.authorK T Lee-
dc.date.accessioned2017-04-19T09:05:01Z-
dc.date.available2017-04-19T09:05:01Z-
dc.date.issued2006-
dc.identifier.issn0250-6807-
dc.identifier.uri10.1159/000095353ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7545-
dc.description.abstractSynthetic oil containing diacylglycerol and monoacylglycerol, called 'functional oil' (FO), was newly produced and evaluated for its putative anti-atherosclerotic potential by in vitro assays and in vivo test using hypercholesterolemic mice (C57BL/6). The FO revealed good inhibitory activities against both liver acyl-CoA:cholesterol acyltransferase and serum lipoprotein-associated phospholipase A2. The FO showed enhanced activities on lipoprotein interaction such as HDL particle rearrangement to produce different sizes of HDL species. In control mice, hypercholesterolemia was induced by consumption of high-cholesterol, high-fat (HCHF) diet that contained 1.25% cholesterol/15% fat/0.5% Na-cholate with or without 5% of corn oil. In experimental mice, 5% of the FO + HCHF diet was fed during the same period. After the 4-week administration of the diet, serum total cholesterol concentration of the FO-fed group decreased by 38 or 20% when compared to the HCHF diet control group or corn oil (99.9% of triacylglycerol) diet group, respectively. The percentage of HDL cholesterol to total cholesterol was 36% of HDL cholesterol in the FO-fed group, while the HCHF control group and corn oil-fed group showed 21 and 25%, respectively. These results indicate that the FO possesses a blood cholesterol-lowering effect in mouse model and inhibition effects against the atherogenic enzymes.-
dc.publisherKarger-
dc.titleAnti-atherosclerotic effect of a new synthetic functional oil containing mono-and diacylglycerol from corn oil-
dc.title.alternativeAnti-atherosclerotic effect of a new synthetic functional oil containing mono-and diacylglycerol from corn oil-
dc.typeArticle-
dc.citation.titleAnnals of Nutrition and Metabolism-
dc.citation.number5-
dc.citation.endPage475-
dc.citation.startPage467-
dc.citation.volume50-
dc.contributor.affiliatedAuthorJong Min Han-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.alternativeName조경현-
dc.contributor.alternativeName한종민-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName이종호-
dc.contributor.alternativeName이정희-
dc.contributor.alternativeName이기택-
dc.identifier.bibliographicCitationAnnals of Nutrition and Metabolism, vol. 50, no. 5, pp. 467-475-
dc.identifier.doi10.1159/000095353-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordDiacylglyceride-
dc.subject.keywordHypercholesterolemia-
dc.subject.keywordLipoproteins-
dc.subject.keywordMonoacylglyceride-
dc.subject.localatherosclerosis-
dc.subject.localAtherosclerosis-
dc.subject.localatheroclerosis-
dc.subject.localDiacylglyceride-
dc.subject.localHypercholesterolemia-
dc.subject.localhypercholesterolemia-
dc.subject.localLipoproteins-
dc.subject.locallipoprotein-
dc.subject.localLipoprotein-
dc.subject.locallipoproteins-
dc.subject.localMonoacylglyceride-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.