Inhibition of protein tyrosine phosphatase 1B by prenylated isoflavonoids isolated from the stem bark of Erythrina addisoniae

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dc.contributor.authorEun Young Bae-
dc.contributor.authorMin Kyun Na-
dc.contributor.authorD Njamen-
dc.contributor.authorJ T Mbafor-
dc.contributor.authorZ T Fomum-
dc.contributor.authorL Cui-
dc.contributor.authorDong-Ho Choung-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorWon Keun Oh-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T09:05:03Z-
dc.date.available2017-04-19T09:05:03Z-
dc.date.issued2006-
dc.identifier.issn0032-0943-
dc.identifier.uri10.1055/s-2006-946674ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7560-
dc.description.abstractIt has been suggested that protein tyrosine phosphatase IB (PTP1B) inhibitors might be a therapeutic target for the treatment of type 2 diabetes and obesity. A bioassay-guided phytochemical study of the EtOAc extract of the stem bark of Erythrina addisoniae (Leguminosae) resulted in the identification of a new PTP1B inhibitory compound, 5,2′4′-trihydroxy-6-(γ, γ-dimethylallyl)-2?,2?-dimethyldihydropyrano[5?, 6?]isoflavanone (6), along with five known prenylated isoflavonoids, orientanol E (1), senegalensin (2), warangalone (3), warangalone 4′-methyl ether (4) and 2,3-dihydroauriculatin (5). Compounds 1, 5 and 6 inhibited PTP1B with IC50 values ranging from 2.6 ± 0.5 to 10.1 ± 0.3 μM. Our results indicate that hydroxylation at both 2′- and 4′-positions in the B-ring and cyclization between a hydroxy group at C-7 and one of the prenyl groups at C-6 or C-8 in the A-ring may be important for activity. Thus, compounds 5 and 6 could be a new class of natural PTP1B inhibitors.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleInhibition of protein tyrosine phosphatase 1B by prenylated isoflavonoids isolated from the stem bark of Erythrina addisoniae-
dc.title.alternativeInhibition of protein tyrosine phosphatase 1B by prenylated isoflavonoids isolated from the stem bark of Erythrina addisoniae-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number10-
dc.citation.endPage948-
dc.citation.startPage945-
dc.citation.volume72-
dc.contributor.affiliatedAuthorEun Young Bae-
dc.contributor.affiliatedAuthorDong-Ho Choung-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName배은영-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeNameNjamen-
dc.contributor.alternativeNameMbafor-
dc.contributor.alternativeNameFomum-
dc.contributor.alternativeNameCui-
dc.contributor.alternativeName정동호-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationPlanta Medica, vol. 72, no. 10, pp. 945-948-
dc.identifier.doi10.1055/s-2006-946674-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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